Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy
Article first published online: 4 MAR 2010
Acta Psychiatrica Scandinavica
Volume 104, Issue 6, pages 411–422, December 2001
How to Cite
Hageman, I., Andersen, H. S. and Jørgensen, M. B. (2001), Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy. Acta Psychiatrica Scandinavica, 104: 411–422. doi: 10.1034/j.1600-0447.2001.00237.x
- Issue published online: 4 MAR 2010
- Article first published online: 4 MAR 2010
- Accepted for publication September 10, 2001
Objective: To review the literature on the psychobiology and pharmacotherapy of PTSD.
Method: Relevant studies were identified by literature searches (Pub-med, web of science) and through reference lists. The search was ended by May 2001.
Results: There is evidence of involvement of opioid, glutamatergic, GABAergic, noradrenergic, serotonergic and neuroendocrine pathways in the pathophysiology of PTSD. Medications shown to be effective in double-blind placebo-controlled trials includes selective serotonin reuptake inhibitors, reversible and irreversible MAO-inhibitors, tricyclic antidepressants and the anticonvulsant lamotrigine. Still more agents appear promising in open-label trials.
Conclusion: The complexity of the psychobiology is reflected by the difficulties in treating the disorder. According to the present knowledge, suggestions for drug treatment of PTSD are made.