Could the hypofrontality pattern in schizophrenia be modified through neuropsychological rehabilitation?
Article first published online: 23 SEP 2008
Acta Psychiatrica Scandinavica
Volume 105, Issue 3, pages 202–208, March 2002
How to Cite
Penadés, R. , Boget, T. , Lomeña, F. , Mateos, J. J. , Catalán, R. , Gastó, C. and Salamero, M. (2002), Could the hypofrontality pattern in schizophrenia be modified through neuropsychological rehabilitation?. Acta Psychiatrica Scandinavica, 105: 202–208. doi: 10.1034/j.1600-0447.2002.1o421.x
- Issue published online: 23 SEP 2008
- Article first published online: 23 SEP 2008
- cognitive deficit;
Objective: The effects of neuropsychological treatment on cognitive hypofrontality were examined in schizophrenic patients through the score activation.
Method: Eight subjects (six men and two women) with persistent negative symptoms and cognitive impairments were evaluated with single photon emission computed tomography (SPECT) procedures and neuropsychological battery before and after a neuropsychological treatment group.
Results: After treatment an enhancement in neuropsychological performance was found, especially in executive functions. The activation score showed an increase over baseline levels and no cognitive-dependent hypofrontality after treatment was found. Although the prefrontal blood flow changes were small and non-specific, they suggest a reduction of the cognitive hypofrontality after neuropsychological treatment.
Conclusion: Cognitive improvements after neuropsychological treatment would possibly be related with the diminution of the functional hypoactivity in the prefrontal areas.