No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis

Authors

  • E. Robertson,

    1. Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Search for more papers by this author
  • I. Jones,

    1. Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Search for more papers by this author
  • F. Middle,

    1. Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Search for more papers by this author
  • J. Moray,

    1. Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Search for more papers by this author
  • N. Craddock

    1. Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Search for more papers by this author

Joint corresponding authors Dr Ian Jones, University of Birmingham, Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, Edgbaston, Birmingham, B15 2QZ, UK, E-mail: i.r.jones@bham.ac.uk

Prof Nick Craddock, Neuropsychiatric Genetics Unit, Department of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK E-mail: craddockn@cf.ac.uk

Abstract

Objective: To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis.

Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group).

The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth.

Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism.

Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.

Ancillary