Aging and outcome in schizophrenia
Article first published online: 12 MAY 2003
Acta Psychiatrica Scandinavica
Volume 107, Issue 5, pages 336–343, May 2003
How to Cite
Jeste, D. V., Twamley, E. W., Eyler Zorrilla, L. T., Golshan, S., Patterson, T. L. and Palmer, B. W. (2003), Aging and outcome in schizophrenia. Acta Psychiatrica Scandinavica, 107: 336–343. doi: 10.1034/j.1600-0447.2003.01434.x
- Issue published online: 12 MAY 2003
- Article first published online: 12 MAY 2003
- Accepted for publication October 11, 2002
- middle age;
- psychotic disorders
Objective: Controversy exists about long-term outcome of schizophrenia, but few studies have compared older out-patients to normal subjects. We sought to examine the relationship of age to clinical features, psychopathology, movement abnormalities, quality of well-being, and everyday functioning in schizophrenia out-patients and normal comparison subjects, and to further characterize these outcomes in elderly schizophrenia out-patients.
Method: A total of 290 out-patients and 144 comparison subjects, aged 40–85 years, underwent comprehensive assessments.
Results: Among patients, aging was associated with decreased psychopathology, even after controlling for duration of illness. There was no accelerated aging-related decline on any measure in the patients. Yet, elderly patients were more impaired than comparison subjects on various measures.
Conclusion: The course of schizophrenia in late life appears stable, but most elderly patients remain symptomatic and impaired. Our findings dispute notions of either progressive deterioration or marked improvement in aging schizophrenia out-patients.