Methylphenidate and intracortical excitability: opposite effects in healthy subjects and attention-deficit hyperactivity disorder
Article first published online: 10 JAN 2003
Acta Psychiatrica Scandinavica
Volume 107, Issue 1, pages 69–72, January 2003
How to Cite
Moll, G. H., Heinrich, H. and Rothenberger, A. (2003), Methylphenidate and intracortical excitability: opposite effects in healthy subjects and attention-deficit hyperactivity disorder. Acta Psychiatrica Scandinavica, 107: 69–72. doi: 10.1034/j.1600-0447.2003.02114.x
- Issue published online: 10 JAN 2003
- Article first published online: 10 JAN 2003
- Accepted for publication October 2, 2002
- intracortical excitability;
- attention-deficit hyperactivity disorder;
- healthy adults
Objective: To test the effects of a standard dosage of the psychostimulant methylphenidate (MPH) – which significantly enhances intracortical inhibition but had no effects on intracortical facilitation in children with attention-deficit hyperactivity disorder (ADHD) – on intracortical excitability in healthy subjects.
Method: In 12 healthy subjects, aged 20–40 years, intracortical inhibition and facilitation were investigated before and 70 min after the intake of 10 mg MPH using the technique of transcranial magnetic stimulation (TMS) with the paired-stimulus paradigm.
Results: In comparison of the two TMS measurements, a significant enhancement in intracortical facilitation but no effects on intracortical inhibition could be stated under MPH administration.
Conclusion: This study provides first evidence for opposite effects of MPH on intracortical excitability in healthy adult subjects showing enhanced intracortical facilitation in contrast to ADHD children in whom enhanced intracortical inhibition has recently been shown.