Change of immunoglobulins and complement factors in patients with self-injurious behaviour
Article first published online: 17 JAN 2003
Acta Psychiatrica Scandinavica
Volume 107, Issue 2, pages 151–154, February 2003
How to Cite
Moe, T. J., Mykletun, A., Matre, R., Skovlund, E., Bassøe, C.-F. and Dahl, A. A. (2003), Change of immunoglobulins and complement factors in patients with self-injurious behaviour. Acta Psychiatrica Scandinavica, 107: 151–154. doi: 10.1034/j.1600-0447.2003.02119.x
- Issue published online: 17 JAN 2003
- Article first published online: 17 JAN 2003
- Accepted for publication October 15, 2002
- attempted suicide;
- complement C3, C4;
- immunoglobulins IgG;
Objective: As stress activates the inflammatory response system, and attempted suicide is connected with severe stress, we hypothesized that patients hospitalized for self-injurious behaviour have changed immunocompetence.
Method: The concentration of immunoglobulins IgG, IgA, IgM, and the complement components C3 and C4 in 73 patients hospitalized for self-injurious behaviour was compared with those of 122 healthy controls. The immunoglobulins and complement were quantified by nephelometric technique.
Results: The levels of IgG and IgM were significantly lower, and the complement C3 and C4 were significantly higher in self-injurious patients compared with controls. This was valid in both genders and the effects did not interact with gender.
Conclusions: This controlled study showed that the concentrations of immunoglobulins were reduced and complement components were increased in patients who are admitted to hospital for self-injurious behaviour.