Cerebral tissue alterations and daily life stress experience in psychosis
Article first published online: 10 JAN 2003
Acta Psychiatrica Scandinavica
Volume 107, Issue 1, pages 54–59, January 2003
How to Cite
Marcelis, M., Myin-Germeys, I., Suckling, J., Woodruff, P., Hofman, P., Bullmore, E., Delespaul, P. and Van Os, J. (2003), Cerebral tissue alterations and daily life stress experience in psychosis. Acta Psychiatrica Scandinavica, 107: 54–59. doi: 10.1034/j.1600-0447.2003.02177.x
- Issue published online: 10 JAN 2003
- Article first published online: 10 JAN 2003
- Accepted for publication July 22, 2002
- magnetic resonance imaging;
- life stress
Objective: To examine whether the total volumes of cerebrospinal fluid (CSF), cerebral grey matter and white matter were correlated with the experience of environmental stress in daily life situations.
Method: Twenty-seven patients with psychosis underwent magnetic resonance imaging scanning and a random time-sampling self-assessment technique (Experience Sampling Method) to determine subjective daily life stress experiences. Total cerebral tissue volumes were derived from an automated segmentation procedure.
Results: CSF volume was positively associated with daily life event-related stress (β=0.016, P=0.002), while the association with total white matter was negative (β=−0.013, P=0.005). The effects were independent of each other and of total cerebral volume and other confounders. No large or significant association was found with grey matter volume.
Conclusion: Subjective stress experience in daily life is associated with increased CSF and reduced white matter volumes in patients with psychosis, suggesting functional significance of these cerebral measures.