Complementary Use of Scintimammography with 99m-Tc-Mibi to Triple Diagnostic Procedure in Palpable and Non-Palpable Breast Lesions
Article first published online: 12 MAY 2003
Volume 44, Issue 3, pages 288–293, May 2003
How to Cite
Wilczek, B., Aspelin, P., Boné, B., Pegerfalk, A., Frisell, J. and Danielsson, R. (2003), Complementary Use of Scintimammography with 99m-Tc-Mibi to Triple Diagnostic Procedure in Palpable and Non-Palpable Breast Lesions. Acta Radiologica, 44: 288–293. doi: 10.1034/j.1600-0455.2003.00054.x
- Issue published online: 12 MAY 2003
- Article first published online: 12 MAY 2003
- Accepted for publication 17 January 2003.
- breast carcinoma;
- diagnostic accuracy
Purpose: The aim of this study was to determine the clinical value of scintimammography with 99m-Tc-MIBI (Sc) as a complementary method to the triple diagnostic procedure in the diagnosis of breast lesions.
Material and Methods: Ninety-six consecutive patients with 65 palpable and 54 non-palpable breast lesions were included in a prospective study. All lesions were evaluated by clinical examination, mammography and fine-needle-aspiration cytology (FNAC), called triple diagnostic procedure (TD). Prone planar scintimammography with 99m-Tc-MIBI was performed in all patients. Five groups were defined for diagnosis: 1 = normal; 2 = benign; 3 = probably benign; 4 = highly suspect of malignancy; and 5 = malignant. In the calculations, groups 1–3 were considered benign, and 4–5 malignant. All lesions were excised and examined histologically. The additional value of Sc + TD procedure was studied separately for palpable and non-palpable lesions.
Results: Histologically, 83 malignant and 36 benign lesions were found in the 119 breast lesions. Sensitivity for malignancy in palpable lesions of TD alone and of the combination TD + Sc were 95.6% and 100%, respectively. Sensitivity for malignancy in non-palpable lesions of TD and TD + Sc was 89.1% and 97.2%, respectively.
Conclusion: Adding scintimammography to the triple diagnostic procedure increased the sensitivity for the detection of both palpable and non-palpable breast cancers, but decreased the specificity.