Diffusion MR imaging and proton MR spectroscopy
Article first published online: 4 JUL 2003
Volume 44, Issue 4, pages 440–443, July 2003
How to Cite
Sener, R. N. (2003), Metachromatic Leukodystrophy. Acta Radiologica, 44: 440–443. doi: 10.1034/j.1600-0455.2003.00094.x
- Issue published online: 4 JUL 2003
- Article first published online: 4 JUL 2003
- Accepted for publication 3 April 2003.
- Metachromatic leukodystrophy;
- diffusion MR imaging;
- proton MR spectroscopy
Metachromatic leukodystrophy is characterized by dysmyelination caused by a deficiency of arylsulfatase-A. In a 17-month-old boy with metachromatic leukodystrophy, an echo-planar diffusion MR sequence revealed a restricted diffusion pattern in the deep white matter, manifested by high-signal on b = 1000 s/mm2 images, and low ADC values (0.56 × 10−3 mm2/s). Proton MR spectroscopy revealed a marked decrease in choline, a metabolite related to myelin turnover. These observations consisting of a restricted diffusion pattern on diffusion MR imaging, and decreased choline peaks on proton spectroscopy, likely represented dysmyelination in metachromatic leukodystrophy.