Department of Immunotechnology, Lund University, Sweden.
Autoantibody activity of the immunoglobulin secreted by a follicular B-cell lymphoma
Article first published online: 28 JUN 2008
2000 Acta Pathologica, Microbiologica et Immunologica Scandinavica
Volume 108, Issue 11, pages 764–770, July 2000
How to Cite
Barrios, Y., Plaza, A., Cabrera, R. and DÍAz-Espada, F. (2000), Autoantibody activity of the immunoglobulin secreted by a follicular B-cell lymphoma. APMIS, 108: 764–770. doi: 10.1034/j.1600-0463.2000.d01-27.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received August 22, 2000. Accepted October 9, 2000.
- Biclonal lymphoma;
In patients with B-cell lymphoma, only in rare cases a secreted paraprotein is found, and in very few of them an associated autoantibody activity has been demonstrated. Here we report the case of a patient with a low-grade B-cell lymphoma with a serum biclonal paraprotein (G,M)Λ. and severe erythroblastopenia. Indirect immunofluorescence studies of total serum revealed cytoplasmic (Hep-2 cells) and extracellular matrix (rat tissue sections) staining, suggestive of a new specificity. After gel filtration of serum samples, only the IgM-containing fraction showed the same pattern of staining. Tumor-derived hybridomas expressed an unmutated V3–11 gene identical to that found in tumor samples and secreted an IgM immunoglobulin endowed with the same reactivity, which confirms the tumoral origin of the tissue-reactive protein. The results suggest a link between the autoimmune condition in this patient and the novel specificity displayed by the tumor-derived immunoglobulin.