Well-differentiated adenocarcinoma of the gallbladder mimicking minimal deviation adenocarcinoma of the cervix.
Article first published online: 28 JUN 2008
© 2000 APMIS
Volume 108, Issue 3, pages 173–177, January 2000
How to Cite
Tashiro, T., Hirokawa, M., Horiguchi, H., Wakatsuki, S., Sano, T. and Yada, S. (2000), Well-differentiated adenocarcinoma of the gallbladder mimicking minimal deviation adenocarcinoma of the cervix. APMIS, 108: 173–177. doi: 10.1034/j.1600-0463.2000.d01-41.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received June 30, 1999. Accepted October 18, 1999
- minimal deviation adenocarcinoma;
- adenoma malignum;
- pS2 protein;
- human gastric mucin
We report a case of well-differentiated adenocarcinoma of the gallbladder, histologically mimicking minimal deviation adenocarcinoma (MDA) of the cervix. A 71-year-old Japanese male underwent cholecystectomy because of the suggestion of gallbladder carcinoma. The resected gallbladder showed a localized thickening of the gallbladder wall with a polypoid lesion measuring 12 × 7 mm in diameter. Microscopically, the polypoid lesion proved to be a well-differentiated adenocarcinoma composed of columnar cells with a clear cytoplasm. In the thickened gallbladder wall, well-formed glands were extensively distributed; they were surrounded by a slightly desmoplastic reaction instead of lamina propria, or were directly in contact with smooth muscle cells. The diagnostic criteria for cervical MDA may be useful in distinguishing well-differentiated adenocarcinoma of the gallbladder from benign conditions, such as Rokitansky-Aschoff sinus and adenomyomatosis. It is remarkable that the tumor cells of the present case expressed gastric type mucin which is characteristic of mucinous type cervical MDA.