The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment.


Dr Jürg Schmid, University of Berne, School of Dental Medicine, Freiburg-strasse 7, CH-3010 Berne, Switzerland


A dome-shaped bioresorbable membrane was fixed to the wounded rabbit calvaria and filled with a bioresorbable fibre conglomerate. After 4 weeks, the histologic preparation revealed an intimate spatial and temporal correlation between newly formed blood vessels and de novo extraskeletal bone formation. These observations emnhasize the sipnificance of angiogenesis in guided bone generation.