Osteocalcin, deoxypyridinoline and interleukin-1β in peri-implant crevicular fluid of patients with peri-implantitis

Authors

  • Masashi Murata,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Jun-ichi Tatsumi,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Yumi Kato,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Satoru Suda,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Yasuko Nunokawa,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Yukinao Kobayashi,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Hiroyuki Takeda,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Hisao Araki,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Kitetsu Shin,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Kazuhiro Okuda,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Takashi Miyata,

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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  • Hiromasa Yoshie

    1. Authors' affiliations:Masashi Murata, Yumi Kato, Satoru Suda, Yasuko Nunokawa, Kazuhiro Okuda, Hiromasa Yoshie, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services,Jun-ichi Tatsumi, Yukinao Kobayashi, Hiroyuki Takeda, Kitetsu Shin, Takashi Miyata, Department of Periodontology,Hisao Araki, Post-doctoral Institute of Clinical Dentistry, Meikai University School of Dentistry, Meikai, Japan
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Hiromasa Yoshie, PhD. and DDS.
Division of Periodontology
Department of Oral Biological Science
Niigata University Graduate School of Medical and Dental Sciences
Gakko-cho 2–5274
Niigata 951–8514
Japan
Tel: + 81 25 227 2869
Fax: + 81 25 227 0808

Abstract

Abstract: The aim of the present study was to analyze the levels of osteocalcin, deoxypyridinoline (Dpd) and interleukin-1β as markers of bone metabolism in peri-implant crevicular fluid (PICF) from peri-implantitis patients. PICF was sampled from a total of 34 endosseous titanium implants from 16 patients; nine females (mean age 52.8, range 40–62 years) and seven males (mean age 56.0, range 36–66 years). The implants had been in place for a period of 9–112 months (mean; 35.8 months) since the loading. These sites were categorized as six peri-implantitis, eight peri-implant mucositis and 20 healthy implant. PICF volume from peri-implantitis sites was significantly higher than mucositis and healthy implant sites (P < 0.01). Osteocalcin levels in PICF from mucositis sites were significantly higher than healthy implants (P < 0.05), whereas peri-implantitis sites were not significantly different from either mucositis or healthy implant sites. Dpd could not be detected in any of the samples examined. IL-1β levels in PICF from peri-implantitis sites were significantly higher than levels from peri-implant mucositis (P < 0.05) and healthy implant sites (P < 0.01). In conclusion, osteocalcin in PICF may reflect increased local bone turnover around implants. Further, IL-1β should be a useful marker for peri-implant inflammation.

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