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Keywords:

  • enhancer;
  • irritant contact dermatitis;
  • occlusion, percutaneous absorption-penetration;
  • stratum corneum;
  • transdermal therapeutic systems;
  • transepidermal water loss.

Occlusion, widely used to enhance percutaneous absorption of drugs, also increases penetration of other chemicals and antigens, and hence may exacerbate irritant and allergic contact dermatitis. This overview summarizes the adverse effects of occlusion.