Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature
Article first published online: 12 FEB 2002
Journal of Cutaneous Pathology
Volume 29, Issue 1, pages 59–62, January 2002
How to Cite
Reis-Filho, J. S., Milanezi, F., Soares, M. F., Fillus-Neto, J. and Schmitt, F. C. (2002), Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature. Journal of Cutaneous Pathology, 29: 59–62. doi: 10.1034/j.1600-0560.2002.290112.x
- Issue published online: 12 FEB 2002
- Article first published online: 12 FEB 2002
- Accepted June 14, 2001
Background: Spindle cell/pleomorphic lipoma (SC/PL) is a benign adipose tissue tumor that usually affects the subcutaneous tissues of shoulders, backs, and neck region of middle-aged male patients. Histologically, it is characterized by the presence of primitive CD34-positive spindle cells arranged in short fascicles, bizarre floret-like multinucleated giant cells, mature adipocytes, and a small number of lipoblasts. Recently, an intradermal subset has been described, which mainly affects female patients and presents a wider antomical distribution when compared to the classical variant of SC/PL.
Methods: We report a case of intradermal SC/PL affecting the labium majus of a 56-year-old female patient.
Results: The histological examination disclosed the typical histological features, however the lesion showed poorly demarcated and infiltrative borders, as well as involvement of dermal nerves. The immunohistochemical analysis according to streptovidin-biotin-peroxidase technique showed immunoreactivity for CD34 and vimentin in the spindle cells, as well as S100 protein and vimentin in the adipocytic cells.
Conclusions: To the best of our knowledge, this is the first case of intradermal SC/PL affecting the vulvar region. Care must be taken not to misdiagnosis this rare tumor as well-differentiated liposarcoma, cellular angiofibroma, solitary fibrous tumor, and cutaneous neurofibroma.