Primary cutaneous CD30 (Ki-1)-positive non-anaplastic B-cell lymphoma
Article first published online: 23 APR 2002
Journal of Cutaneous Pathology
Volume 29, Issue 3, pages 181–184, March 2002
How to Cite
Herrera, E., Gallardo, M., Bosch, R., Cabra, B., Aneri, V. and Sánchez, P. (2002), Primary cutaneous CD30 (Ki-1)-positive non-anaplastic B-cell lymphoma. Journal of Cutaneous Pathology, 29: 181–184. doi: 10.1034/j.1600-0560.2002.290310.x
- Issue published online: 23 APR 2002
- Article first published online: 23 APR 2002
- Accepted July 5, 2001
Background: The CD30 (Ki-1)-positive lymphoproliferative disorders show a non-epidermotropic infiltrate of large-sized pleomorphic T cells, being extremely rare those that develop from B cells.
Clinical case: A 51-year-old white man presented with a 8×10 cm lobulated scalp tumor that had developed during the previous 8 months. Histopathology demonstrated a proliferation of medium and large-sized non-anaplasic lymphocytes. The tumor cells (CD45+) expressed B phenotype (CD20+, CD3) and were CD30 (Ki-1) positive. The extension study revealed no extracutaneous involvement and the lesion resolved following chemotherapy. Two years later, after six cycles of chemotherapy that followed the CHOP protocol the patient remained asymptomatic.
Conclusions: We report a patient with a diffuse lymphoma of medium and large-sized B phenotype cells on the scalp that showed the unusual characteristic of being both non-anaplastic and CD30 (Ki-1) positive.