Expression of neurotrophin receptor Trk-C in nevi and melanomas
Article first published online: 7 MAY 2003
Journal of Cutaneous Pathology
Volume 30, Issue 5, pages 318–322, May 2003
How to Cite
Xu, X., Tahan, S. R., Pasha, T. L. and Zhang, P. J. (2003), Expression of neurotrophin receptor Trk-C in nevi and melanomas. Journal of Cutaneous Pathology, 30: 318–322. doi: 10.1034/j.1600-0560.2003.00068.x
- Issue published online: 7 MAY 2003
- Article first published online: 7 MAY 2003
- Accepted for publication December 17, 2002
Background: Neurotrophins (NTs) are growth factors for neurons and other neural crest-derived cells. Their functions are mediated by 75-kDa low-affinity glycoprotein receptor (p75) NT receptor and a family of tyrosine kinase receptors (Trks) that includes Trk-A, -B, and -C. Signal transduction through the Trk receptors has been shown to regulate growth and apoptosis of tumors of neuronal origin. In addition, Trk oncogenes have been shown to be rearranged in some non-neuronal neoplasms. Recently, immunoexpression of NT-3 has been shown to be significantly higher in melanomas than in banal nevi on cryostat tissue.
Methods: Since the biologic function of NT-3 is mediated primarily through Trk-C, we investigated Trk-C immunoexpression on paraffin sections of 10 compound nevi and 63 melanomas.
Results: The expression of Trk-C was relatively low in compound nevi (30%). Trk-C expression was overall 62% in melanomas of various stages. Our data show that the expression of Trk-C increased as melanoma progressed from in situ (58%) to papillary dermal invasion (91%), and then declined in deeper (57%) and metastatic melanomas (31%).
Conclusion: These findings suggest a possible role of Trk-C in the progression of early stages of melanoma.