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Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia


Dr M.F. Leahy, Consultant Haematologist, Department of Haematology, Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia
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Abstract: Tranexamic acid (an antifibrinolytic agent) is of proven benefit in the treatment of bleeding in patients with congenital and acquired coagulation disorders. We report the case of a patient with an acquired Factor VIII inhibitor, who was on a prophylactic dose of tranexamic acid because of recurrent bleeding episodes and developed a pulmonary embolism. Although studies using tranexamic acid have not shown a definite increased risk for the development of venous thrombosis, this is the likely cause of the pulmonary embolism in this patient.

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