Mast cell modulation of immune responses to bacteria
Article first published online: 4 JAN 2002
Volume 179, Issue 1, pages 16–24, February 2001
How to Cite
Malaviya, R. and Abraham, S. N. (2001), Mast cell modulation of immune responses to bacteria. Immunological Reviews, 179: 16–24. doi: 10.1034/j.1600-065X.2001.790102.x
- Issue published online: 4 JAN 2002
- Article first published online: 4 JAN 2002
- Cited By
Summary: Mast cells are key elements of the immune system. These cells release a wide variety of pro-inflammatory mediators which are responsible for the pathophysiology of many allergic diseases. Recent studies, however, have shown that mast cells have the capacity to modulate the host's innate immune response to gram negative bacteria by their ability to phagocytose bacteria, process and present bacterial antigens to T cells and recruit phagocytic help through the release of physiological amounts of pro-inflammatory mediators. Here, current knowledge of mast cell responses to gram negative bacteria and molecular mechanisms associated with mast cell bacteria interaction is reviewed.
This work was supported in part by NIH research grant AI45013. We are grateful to Ms. Tamara Paul for critical review of the manuscript.