Cell adhesion and polarity during immune interactions

Authors

  • María C. Montoya,

    1. Authors' addressMaría C. Montoya, David Sancho, Miguel Vicente-Manzanares, Francisco Sánchez-Madrid,Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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  • David Sancho,

    1. Authors' addressMaría C. Montoya, David Sancho, Miguel Vicente-Manzanares, Francisco Sánchez-Madrid,Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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  • Miguel Vicente-Manzanares,

    1. Authors' addressMaría C. Montoya, David Sancho, Miguel Vicente-Manzanares, Francisco Sánchez-Madrid,Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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  • Francisco Sánchez-Madrid

    1. Authors' addressMaría C. Montoya, David Sancho, Miguel Vicente-Manzanares, Francisco Sánchez-Madrid,Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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  • María C. MontoyaDavid SanchoMiguel Vicente-ManzanaresFrancisco Sánchez-Madrid


Francisco Sánchez-Madrid
Servicio de Inmunología
Hospital de la Princesa
Universidad Autónoma de Madrid
C/Diego de Léon 62
28006 Madrid
Spain
Tel: + 34 91 5202370
Fax: + 34 91 5202374
e-mail: fsanchez@hlpr.insalud.es

Abstract

Summary: Intercellular interactions are critical for a coordinated function of different cell types involved in the immune response. Here we review the cellular and molecular events occurring during cell–cell immune contacts. Cognate naïve CD4+ T lymphocyte-dendritic cell (DC) and primed T cell–antigen-presenting B lymphocyte interactions are discussed. The engagement of cytotoxic T lymphocytes (CTL) or natural killer cells (NK) with their targets is analyzed and compared to the process of T cell–antigen-presenting cell (APC) conjugate formation. The immunological synapse, a complex cluster of molecules organized at the contact area of cell conjugates, exhibits common features but shows some differences depending on cell types involved. Cellular interactions occur in sequential stages that involve dramatic changes in cell polarity and dynamic redistribution of cell membrane receptors. The role of membrane microdomains, adaptor molecules and the cytoskeleton in the regulation of the molecular reorganization at cell–cell contacts is also discussed.

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