The TCR ADAPts to integrin-mediated cell adhesion

Authors

  • Erik J. Peterson

    Corresponding author
    1. Author's address
      Division of Rheumatology, Department of Medicine and the Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
      Erik J. Peterson, M.D.
      BSBE 6–122
      Center for Immunology
      312 Church Street
      Minneapolis, MN 55455
      USA
      Tel: + 1 612 625 5634
      Fax: + 1 612 625 2199
      e-mail: peter899@umn.edu
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Erik J. Peterson, M.D.
BSBE 6–122
Center for Immunology
312 Church Street
Minneapolis, MN 55455
USA
Tel: + 1 612 625 5634
Fax: + 1 612 625 2199
e-mail: peter899@umn.edu

Abstract

Summary: Adapter proteins regulate leukocyte signal transduction through recruitment of effector molecules to multiprotein complexes. Recent studies in Adhesion and Degranulation promoting Adapter Protein (ADAP)-deficient mice have established that the cytoplasmic phosphoprotein ADAP is required for optimal, mature T-cell proliferation. Furthermore, ADAP plays a key role in T-cell antigen receptor (TCR)-mediated ‘inside out’ signaling leading to integrin activation and to enhanced cellular adhesion to integrin ligands. ADAP associates physically with molecules known to play roles in the regulation of TCR-stimulated actin polymerization. These associations support the hypothesis that ADAP functions in actin cytoskeletal reorganization leading to cellular adhesion and activation.

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