GTPases and T cell activation
Version of Record online: 2 APR 2003
Volume 192, Issue 1, pages 122–130, April 2003
How to Cite
Cantrell, D. A. (2003), GTPases and T cell activation. Immunological Reviews, 192: 122–130. doi: 10.1034/j.1600-065X.2003.00028.x
- Issue online: 2 APR 2003
- Version of Record online: 2 APR 2003
Summary: Guanine nucleotide binding proteins rapidly cycle between a guanosine diphosphate (GDP)-bound and guanosine triphosphate (GTP)-bound state, and they operate as binary switches that control cell activation in response to environmental cues. GTPases adopt different conformations when binding GTP vs. GDP. The GTP-bound state is generally considered to be the active conformation that allows GTPases to interact with downstream effectors and thereby initiate downstream signaling pathways, which regulate many important biological processes. Many members of the Ras family of GTPases, notably Ras and Rap1A, and the Rho family GTPases, Cdc42Hs, Rac1, Rac2 and RhoA, are important components of signal transduction pathways used by antigen receptors, costimulatory, cytokine and chemokine receptors to regulate the immune response. This review discusses current knowledge and ideas about the regulation and function of these GTPases in lymphocytes.