Extrafollicular antibody responses
Article first published online: 7 JUL 2003
Volume 194, Issue 1, pages 8–18, August 2003
How to Cite
MacLennan, I. C. M., Toellner, K.-M., Cunningham, A. F., Serre, K., Sze, D. M.-Y., Zúñiga, E., Cook, M. C. and Vinuesa, C. G. (2003), Extrafollicular antibody responses. Immunological Reviews, 194: 8–18. doi: 10.1034/j.1600-065X.2003.00058.x
- Issue published online: 7 JUL 2003
- Article first published online: 7 JUL 2003
Summary: In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.