The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity


Dr Martin Lipp
Department of Molecular Tumor Genetics and Immunogenetics
Max-Delbrück-Center for Molecular Medicine (MDC)
Robert-Rössle-Straße 10
13092 Berlin
Tel.: +49 30 9406 2886
Fax: +49 30 9406 3884


Summary:  The development of secondary lymphoid organs is a complex process dependent on a coordinated interaction of cells of hematopoietic and non-hematopoietic origin. In this context, chemokines and cytokines belonging to the tumor necrosis factor (TNF)/lymphotoxin (LT) family are critical signaling molecules during the initial steps of lymph node and Peyer's patch organogenesis. Homeostatic chemokines, such as CXCL13, CCL21, and CCL19, as well as their corresponding receptors, CXCR5 and CCR7, have now been shown to closely cooperate in the development of lymphoid organs and the maintenance of lymphoid tissue microarchitecture. We summarize recent data on the function of CXCR5 and CCR7 and their intricate connection to the TNF/LT system in order to refine the current model of lymphoid organ development.