BB rat lyp mutation and Type 1 diabetes

Authors

  • Sheela Ramanathan,

    1. Arthritis and Immune Disorder Research Centre at the University Health Network, and the Departments of Medicine and Immunology at the University of Toronto, Ontario, Canada
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  • Philippe Poussier

    Corresponding author
    1. Arthritis and Immune Disorder Research Centre at the University Health Network, and the Departments of Medicine and Immunology at the University of Toronto, Ontario, Canada
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Correspondence to: Philippe Poussier
Sunnybrook and Wornen's College Health Sciences Centre
2075 Bayview Avenue
Room A-338
Toronto, ON
M4N3M5
Canada
Tel: 1 416 480 6136
Fax: 1 416 480 4375
e-mail: ppoussie@sten.sunnybrook.utoronto.ca

Abstract

Summary: BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.

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