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Expression of p57/Kip2 protein in extrahepatic bile duct carcinoma and intrahepatic cholangiocellular carcinoma


Nariaki Matsuura, Department of Pathology, School of Allied Health Science, Osaka University Faculty of Medicine, 1-7, Yamadaoka, Suita, Osaka 565-0871, Japan. Tel: 81 6 6879 2591, 2595. Fax: 81 6 6879 2499. E-mail:


Abstract:  Background: Evaluation of the biological character of carcinomas requires understanding of cell cycle regulators. P57 (Kip2) belongs to the Cip/Kip family and is known to be one of the universal negative regulators of cell cycle.

Methods: In the present study, therefore, we investigated p57 expression in 37 extrahepatic bile duct carcinomas (BDC) and 28 intrahepatic cholangiocellular carcinomas (CCC).

Results: The average p57 labeling index (LI) in BDC and CCC were 60.8 ± 7.9 and 58.6 ± 18.6, respectively, which were significantly lower (p = 0.0008 and p = 0.0408, respectively) than those in normal duct epithelia (73.1 ± 7.9, 70.4 ± 8.2). p57 LI was significantly lower in BDC and CCC cases with biological aggressive phenotypes such as poor differentiation (p = 0.0260 and p = 0.0069), lymph node metastasis (p = 0.0274 and p = 0.0214), high Ki-67 LI (p = 0.0164 and p = 0.0343) and cyclin D1 overexpression (p = 0.0359 and p = 0.0255).

Conclusion: These findings suggest that decreased p57 expression is related to the increased activity of cell proliferation and also the progression of these carcinomas.

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