• 1
    Roskams T, Desmet V. Ductular reaction and its diagnostic significance. Semin Diagn Pathol 1998; 15: 25969.
  • 2
    Sirica A E. Ductular hepatocytes. Histol Histopathol 1995; 10: 43356.
  • 3
    Demetris A J, Seaberg E C, Wennerberg A, Ionellie J, Michalopoulos G. Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am J Pathol 1996; 149: 43948.
  • 4
    Thung S N. The development of proliferating ductular structures in liver disease. An immunohistochemical study. Arch Pathol Lab Med 1990; 114: 40711.
  • 5
    Gerber M A, Thung S N, Shen S, Stromeyer F W, Ishak K. Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver. Am J Pathol 1983; 110: 704.
  • 6
    Fiel M I, Antonio L B, Nalesnik M A, Thung S N, Gerber M A. Characterization of ductular hepatocytes in primary liver allograft failure. Mod Pathol 1997; 10: 34853.
  • 7
    Haque S, Haruna Y, Saito K, et al. Identification of bipotential progenitor cells in human liver regeneration. Lab Invest 1996; 75: 699705.
  • 8
    Sell S. Liver stem cells. Mod Pathol 1994; 7: 10512.
  • 9
    Park Y N, Brody R I, Sigal S HH, Thung S N, Theise N D. OV-6 positive, HepParl negative oval-like cells in human livers with hepatitis C cirrhosis or with acetaminophen toxicity. Hepatology 1995; 22: 230A.
  • 10
    Germain L, Goyette R, Marceau N. Differential cytokeratin and alphafetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis. Cancer Res 1985; 45: 67381.
  • 11
    Lemire J M, Shiwiri N, Fausto N. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by d-galactosamine. Am J Pathol 1991; 139: 53552.
  • 12
    Evarts R P, Nagy P, Marsden E. In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver. Cancer Res 1987; 47: 546975.
  • 13
    Evarts R P, Nakatsukasa H, Marsden E R. Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat. Cancer Res 1990; 50: 343944.
  • 14
    Grisham J W. Cell types in long-term propagable cultures of rat liver. Ann NY Acad Sci 1980; 349: 12837.
  • 15
    Evarts R P, Nagy P, Marsden E. A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 1987; 8: 173740.
  • 16
    Theise N D, Saxena R, Portmann B C, et al. The canals of Hering and hepatic stem cells in humans. Hepatology 1999; 30: 142533.
  • 17
    Su Q, Liu Y-F, Zhang J-F, Zhang S-X, Li D-F, Yang J-J. Expresion of insulin-like growth factor II in hepatitis B, cirrhosis, and hepatocellular carcinoma: Its relationship with hepatitis B virus antigen expression. Hepatology 1994; 20: 78899.
  • 18
    Hsia C C, Evarts R P, Nakatsukasa H, Marsden E R, Thorgeirsson S S. Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 1992; 16: 132733.
  • 19
    Crosby H A, Hubscher S, Fabris L, et al. Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. Am J Pathol 1998; 152: 7719.
  • 20
    Roskams T, De Vos R, Van Eyken P. Hepatic OV-6 expression in human liver disease and rat experiments. Evidence for hepatic progenitor cells in man. J Hepatol 1998; 29: 45563.
  • 21
    Uchida T, Peters R L. The nature and origin of proliferated bile ductules in alcoholic liver disease. Am J Clin Pathol 1983; 79: 32633.
  • 22
    Scarpelli D G. Multipotent developmental capacity of cells in the adult animal. Lab Invest 1985; 52: 3313.
  • 23
    Desmet W. Modulation of biliary epithelium. In: ReutterW, PopperH, AriasI M, eds. Modulation of Liver Cell Expression. Lancaster: MTP Press 1987: 195214.
  • 24
    Nagore N, Howe S, Boxer L. Liver cell rosettes. Structural differences in cholestasis and hepatitis. Liver 1989; 9: 4351.
  • 25
    Roskams T, Van Den Oord J J, De Vos R. Neuroendocrine features of reactive bile ductules in cholestatic liver disease. Am J Pathol 1990; 137: 101925.
  • 26
    Wennerberg A E, Nalesnik M A, Coleman W B. Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors. Am J Pathol 1993; 143: 15.
  • 27
    Theise N D, Conn M, Thung S N. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol 1993; 24: 1038.
  • 28
    Jorgensen M. A stereological study of intrahepatic bile ducts: 2. Bile duct proliferation in some pathological conditions. Acta Path Microbiol Scand Section A 1973; 81: 6639.
  • 29
    Yamada S, Howe S, Scheuer P J. Three-dimensional reconstruction of biliary pathways in primary biliary cirrhosis: a computer-assisted study. J Pathol 1987; 152: 31723.
  • 30
    Saxena R, Hytiroglou P, Thung S N, Peralta N, Theise N D. Expression of HLA-DR and loss of canals of Hering in early stage primary biliary cirrhosis. Hepatology 1998; 728: 415A.
  • 31
    Hytiroglou P, Tobias H, Abramidou M, Saxena R, Papadimitriou C S, Theise N D. The canals of Hering may represent the primary target of methotrexate toxicity. Hepatology 1998; 28: 603A.