Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy
Article first published online: 21 JUN 2002
Journal of Oral Pathology & Medicine
Volume 31, Issue 5, pages 267–269, May 2002
How to Cite
Femiano, F. and Scully, C. (2002), Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. Journal of Oral Pathology & Medicine, 31: 267–269. doi: 10.1034/j.1600-0714.2002.310503.x
- Issue published online: 21 JUN 2002
- Article first published online: 21 JUN 2002
- Accepted for publication May 14, 2001
- lipoic acid;
- oral dysaesthesia
Background: Burning mouth syndrome (BMS) has features of a neuropathy and could be related to the production of the toxic free radicals that are released in stress situations. Alpha-lipoic acid is an antioxidant able to increase the levels of intracellular glutathione and eliminate free radicals. This study aimed to examine the effectiveness of alpha-lipoic acid in the therapy of BMS.
Method: This was a double blind, controlled study conducted for two months on 60 patients with constant BMS. Comparing alpha-lipoic acid (test) with cellulose starch (placebo), there was no laboratory evidence of deficiencies in iron, vitamins or thyroid function and no hyperglycaemia.
Results and Conclusion: Following treatment with alpha-lipoic acid, there was a significant symptomatic improvement, compared with placebo, with the majority showing at least some improvement after 2 months, thus supporting the hypothesis that burning mouth syndrome is a neuropathy. This improvement was maintained in over 70% of patients at the 1 year follow-up.