A Critical Appraisal of Vitiligo Etiologic Theories. Is Melanocyte Loss a Melanocytorrhagy?
Article first published online: 15 JUL 2003
Pigment Cell Research
Volume 16, Issue 4, pages 322–332, August 2003
How to Cite
Gauthier, Y., Andre, M. C. and Taïeb, A. (2003), A Critical Appraisal of Vitiligo Etiologic Theories. Is Melanocyte Loss a Melanocytorrhagy?. Pigment Cell Research, 16: 322–332. doi: 10.1034/j.1600-0749.2003.00070.x
- Issue published online: 15 JUL 2003
- Article first published online: 15 JUL 2003
- Received 12 May 2003; in final form 31 May 2003
Common generalized vitiligo is an acquired depigmenting disorder characterized by a chronic and progressive loss of melanocytes from the epidermis and follicular reservoir. However, the mechanism of melanocyte disappearance has never been clearly understood, and the intervention of cellular and humoral autoimmune phenomena as primary events remains unproven. In this review, is discussed the data supporting the major theories of vitiligo, namely melanocyte destruction (autoimmune, neural and impaired redox status) and melanocyte inhibition or defective adhesion. Based on recent morphologic findings in vivo supporting a chronic detachment and transepidermal loss of melanocytes in common generalized vitiligo, a new theory is suggested proposing melanocytorrhagy as the primary defect underlying melanocyte loss, integrating most of the possible triggering/precipitating/enhancing effects of other known factors.