Involvement of Cholecystokinin/Gastrin-Related Peptides and their Receptors in Clinical Gastrointestinal Disorders

Authors

  • Robert T. Jensen

    Corresponding author
    1. Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
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Author for correspondence: Dr. Robert T. Jensen, NIH/NIDDK/DDB, Bldg. 10, Rm. 9C-103, 10 Center Dr MSC 1804, Bethesda, MD 20892-1804, USA (fax +1 301 402 0600, e-mail robertj@bdg10.niddk.nih.gov).

Abstract

Abstract: In this paper the possible roles of cholecystokinin (CCK), gastrin, or gastrin-related peptides and their receptors in human gastrointestinal diseases are reviewed. For CCK/CCKA receptors (CCKA-R), the evidence for their proposed involvement in diseases caused by impaired CCK release or CCKA-R mutations, pancreatic disorders (acute/chronic pancreatitis), gastrointestinal motility disorders (gallbladder disease, irritable bowel syndrome), pancreatic tumor growth and satiety disorders, is briefly reviewed. The evidence that has established the involvement of gastrin/CCKB-R in mediating the action of hypergastrinaemic disorders, mediating hypergastrinaemic effects on the gastric mucosa (ECL hyperplasia, carcinoids, parietal cell mass), and acid-peptic diseases, is reviewed. The evidence for their possible involvement in mediating growth of gastric and pancreatic tumours and possible involvement of gastrin-related peptides in colon cancers, is reviewed briefly.

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