Treatment of polymorphic light eruption


Corresponding author:
Dr L.E. Rhodes
University of Manchester
Clinical Sciences Building
Hope Hospital
Manchester, M6 8HD, UK
Tel: 44 161 7871150
Fax: 44 161 7871304


Polymorphic light eruption (PLE) is a highly prevalent photosensitivity disorder, estimated to affect 11–21% people in temperate countries. Typically, PLE appears as a recurrent pruritic eruption comprising papules and/or vesicles and/or plaques, which occurs on photo-exposed skin sites following sun exposure, and which heals without scarring. Commoner in females, the aetiology is uncertain, although there is evidence of an immune basis. We perform a review of the prophylaxis and treatment of this condition. While sun protection, corticosteroids and desensitization phototherapy are the mainstays of management, a range of anti-inflammatory and immunomodulatory agents are reported.