• 1
    Agrawal A, Chandra D, Kale RK. Radiation induced oxidative stress: II studies in liver as a distant organ of tumor bearing mice. Mol Cell Biochem 2001; 224: 917.
  • 2
    Lawrence TS, Robertson JM, Anscher MS, et al. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 1995; 31: 12371248.
  • 3
    Dawson LA, Normolle D, Balter JM et al. Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 2002; 53: 810821.
  • 4
    Ohshima H, Bartsch H. Chronic infections and inflammatory process as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mut Res 1994; 305: 253264.
  • 5
    Abu-shakra A, McQueen ET, Cunnigham ML. Rapid analysis of base-pair substitutions induced by mutagenic drugs through their oxygen radical or epoxide derivatives. Mut Res 2000; 470: 1118.
  • 6
    Jenkins DC, Charles IG, Thomsen LL et al. Role of nitric oxide in tumor growth. Proc Natl Acad Sci 1995; 92: 43924396.
  • 7
    Mahesh SJ, Julie LP, Jack RLJR. Cellular antioxidant and pro-oxidant actions of nitric oxide. Free Rad Biol & Med 1999; 27: 13571366.
  • 8
    Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflammation, and Cancer. Biochemistry (Mosc) 1998; 63: 854865.
  • 9
    Sitasawad SL, Kale RK. Divalent cations and radiation induced lipid peroxidation. Indian J Exp Biol 1994; 32: 5559.
  • 10
    Taysi S, Uslu C, Akcay F et al. Levels of malondialdehyde and nitric oxide in plasma of patients with advanced laryngeal cancer. Surgery Today 2002 (in press).
  • 11
    Bakan E, Taysi S, Polat MF et al. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 2002; 32: 162166.
  • 12
    Stone WL, Papas AM. Tocopherols and the etiology of colon cancer. J Natl Cancer Inst 1997; 89: 10061014.
  • 13
    Tan DX, Reiter RJ, Manchester LC et al. Chemical and physical properties and potential mechanisms: melatonin as a broad-spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002; 2: 181197
  • 14
    Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151180.
  • 15
    Gulcin I, Buyukokuroglu ME, Oktay M et al. On the in vitro antioxidative properties of melatonin. J Pineal Res 2002; 33: 167171.
  • 16
    Vijayalaxmi, Meltz ML, Reiter RJ et al. Melatonin and protection from whole-body irradiation: survival studies in mice. Mut Res 1999; 425: 2127.
  • 17
    Vijayalaxmi, Meltz ML, Reiter RJ et al. Melatonin and protection from genetic damage in blood and bone marrow: whole-body irradiation studies in mice. J Pineal Res 1999; 27: 221225.
  • 18
    Reiter RJ. The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1980; 1: 109131.
  • 19
    Reiter RJ. The ageing pineal gland and its physiological consequences. Bioessays 1992; 14: 169175.
  • 20
    Reiter RJ, Tang L, Garcia JJ et al. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997; 60: Ç22552271.
  • 21
    Reiter RJ, Tan DX, Burkhardt S. Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin. Mech Ageing Dev 2002; 30; 123: 10071019.
  • 22
    Tan DX, Chen LD, Poeggeler B et al. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 5760.
  • 23
    Pieri C, Marra M, Moroni F et al. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 1994; 55: 271276.
  • 24
    Gilad E, Cuzzocrea S, Zingarelli B, et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997; 60: 169174
  • 25
    Reiter RJ. Antioxidant actions of melatonin. Adv Pharmacol 1997; 38: 103117.
  • 26
    Vijayalaxmi, Reiter RJ, Meltz ML. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res 1995; 346: 2331.
  • 27
    Vijayalaxmi, Reiter RJ, Sewerynek E et al. Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiat Res 1995; 143: 102106.
  • 28
    Vijayalaxmi, Reiter RJ, Meltz ML et al. Melatonin: Possible mechanisms involved in its ‘radioprotective’ effect. Mut Res 1998; 404: 187189.
  • 29
    Vijayalaxmi, Reiter RJ, Herman TS et al. Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers. Mut Res 1996 20; 371: 221228.
  • 30
    Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 1978; 19: 10531057.
  • 31
    Moshage H, Kok B et al. Nitrite and nitrate determinations in plasma: A critical evaluation. Clin Chem 1995; 41: 892896.
  • 32
    Bories PN, Bories C. in biological fluids by an enzymatic one step assay with nitrate reductase. Clin Chem 1995; 41: 904907.
  • 33
    Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248254.
  • 34
    Gitto E, Karbownik M, Reiter RJ, et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001; 50: 756760.
  • 35
    Reiter RJ, Tan D-X, Manchester LC et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 2001; 34: 237256.
  • 36
    Acuna-castroviejo D, Martin M, Macias M et al. Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 2001; 30: 6574.
  • 37
    Ohta Y, Kongo M, Kishikawa T. Effect of melatonin on changes in hepatic antioxidant enzyme activities in rats treated with alpha-naphthylisothiocyanate. J Pineal Res 2001; 31: 370377.
  • 38
    Okatani Y, Wakatsuki A, Shinohara K et al. Melatonin stimulates glutathione peroxidase activity in human chorion. J Pineal Res 2001; 30: 199205.
  • 39
    Varshney R, Kale RK. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radiat Biol 1990; 58: 733743.
  • 40
    Kergonou JF, Bernard P, Braquet M et al. Effect of whole-body gamma irradiation on lipid peroxidation in rat tissues. Biochimie 1981; 63: 555559.
  • 41
    Koc M, Büyükokuroglu ME, Taysi S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol Pharm Bull 2002: 25: 656657.
  • 42
    Reiter RJ. Melatonin: Lower the high price of free radicals. News Physiol Sci 2000; 15: 246250.
  • 43
    Bettahi I, Pozo D, Osuna C et al. Melatonin reduces nitric oxide synthase activity in rat hypothalamus. J Pineal Res 1996; 20: 205210.
  • 44
    El-sokkary GH, Omar HM, Hassanein AF et al. Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free Radic Biol Med 2002; 32: 319332.
  • 45
    Hara M, Iigo M, Ohtani-kaneko R et al. Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats. Biol Signals 1997; 6: 90100.
  • 46
    Kotler M, Rodriguez C, Sainz RM et al. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J Pineal Res 1998; 24: 8389.
  • 47
    El-sokkary GH, Reiter RJ, Cuzzocrea S et al. Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan. Shock 1999; 12: 402408.
  • 48
    Pozo D, Reiter RJ, Calvo JR et al. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 1997; 65: 430442.