• 1
    Halliwell B. Effect of diet on cancer development: is oxidative DNA damage a biomarker? Free Radical Biol Med 2002; 32: 968974.
  • 2
    Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 1997; 387: 146163.
  • 3
    Rodriguez H, Jurado J, Laval J, Dizdaroglu M. Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid. Nucleic Acids Res 2000; 28: E75.
  • 4
    Snow ET. A possible roll for chromium (III) in genotoxicity. Environ Health Perspect 1991; 92: 7581.
  • 5
    Singh J, Carlisle DL, Pritchard DE, Paterno SR. Chromium-induced genotoxicity and apoptosis. Oncol Report 1998; 5: 13071318.
  • 6
    Tsou TC, Chen CL, Liu TY, Yang JL. Induction of 8-hydroxydeoxygunosine in DNA by chromium (III) plus hydrogen peroxide and its prevention by scavengers. Carcinogenesis 1996; 17: 103108.
  • 7
    Chatgilialoglu C, O'Neill P. Free radicals associated with DNA damage. Exp Gerontol 2001; 36: 14591471.
  • 8
    Chen KC, Chahill DS, Kasai S, Nishimura S, Loeb LA. 8-hydroxydeoxyhguanosine, an abundant form of oxidative DNA damage, causes G [RIGHTWARDS ARROW] T and A [RIGHTWARDS ARROW] C substitution. J Biol Chem 1996; 267: 166172.
  • 9
    Lopez-Burillo S, Tan DX, Rodriguez-Gallego V et al. Melatonin and its derivatives cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine and 6-methoxymelatonin reduce oxidative DNA damage induced by Fenton reagents. J Pineal Res 2003; 34: 178184.
  • 10
    Qi W, Reiter RJ, Tan DX, Manchester LC, Siu AS, Garcia JJ. Increased levels of oxidatively damaged DNA induced by chromium(III) and H2O2: Protection by melatonin and related molecules. J Pineal Res 2000; 29: 5461.
  • 11
    Webb JL. Effects of more than one inhibitor. In: Enzyme and Metabolic Inhibitors. WebbJL, ed., Academic Press, New York, 1963; pp. 487512.
  • 12
    Halliwell B. Free radicals and antioxidants: a personal view. Nutr Rev 1994; 52: 253265.
  • 13
    Reiter RJ. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995; 9: 526533.
  • 14
    Floyd RA. Mitochondrial damage in neurodegenerative diseases. In: Free Radicals in Brain Physiology and Disorders, PackerL, HiramatsuM, YoshikawaT eds, Academic Press, San Diego, 1996; pp. 313330.
  • 15
    Harman D. Free radicals and age related diseases. In: Free Radicals and Aging, YuBP, ed., CRC Press, Boca Raton, 1993; pp. 205222.
  • 16
    Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998; 56: 359384.
  • 17
    Burkhardt S, Reiter RJ, Tan DX, Hardeland R, Cabrera J, Karbownik M. DNA oxidatively-damaged by chromium (III) and H2O2 is protected by antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid. Int J Biochem Mol Biol 2001; 33: 775783.
  • 18
    Cadenas S, Barja G. Resveratrol, melatonin, vitamin E and PBN protect against renal oxidative DNA damage induced by kidney carcinogen KBrO3. Free Rad Biol Med 1999; 26: 15311537.
  • 19
    Qi W, Reiter RJ, Tan DX et al. Chromium(III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: comparative effects of melatonin, ascorbate, and vitamin E. Environ Health Perspect 2000; 108: 399402.
  • 20
    Qi W, Reiter RJ, Tan DX, Manchester LC, Calvo JR. Melatonin prevents δ-aminolevulinic acid-induced oxidative DNA damage in the presence of Fe2+. Mol Cell Biochem 2001; 218: 8792.
  • 21
    Karbownik M, Reiter RJ, Cabrera J, Garcia JJ. Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage. Mutat Res 2001; 474: 8792.
  • 22
    Gitto E, Tan DX, Reiter RJ et al. Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferroxamine) in rat liver homogenates. J Pharm Pharmacol 2001;53: 13931401.
  • 23
    Sahu SC, Gray GC. Kaempferol-induced nuclear DNA damage and lipid peroxidation. Cancer Lett 1994;85: 159164.
  • 24
    Yamanaka N, Oda O, Nagao S. Green tea catechins such as (−)-epicatechin and (−)-epigallacatechin accelerate Cu2+-induced low density lipoprotein oxidation in propagation phase. FEBS Lett 1997; 401: 230234.
  • 25
    Fukuhara K, Miyata N. Resveratrol as a new type of DNA-cleaving agent. Bioorg Med Chem Lett 1998; 8: 31873192.
  • 26
    Bottu G. The effect of buffers and chelators on the reaction of luminal with Fenton's reagent near neutral pH. J Biolumin Chemilumin 1991; 6: 147151.
  • 27
    Tan DX, Manchester LC, Reiter RJ, Qi W, Karbownik M, Calvo JR. Significance of melatonin in oxidative defense system: reactions and products. Biol Signals Recept 2000; 9: 137159.
  • 28
    Reiter RJ, Tan DX, Manchester LC, Calvo JR. Antioxidative capacity of melatonin. In: Handbook of Antioxidants, 2nd edn. CadenasE, PackerL, eds. Marcel Dekker, New York. 2002; pp. 565613.
  • 29
    Li XJ, Gu J, Lu SD, Sun FY. Melatonin attenuates MPTP-induced dopaminergic neuronal injury associated with scavenging hydroxyl radical. J Pineal Res 2002; 32: 4752.
  • 30
    Hsu CH, Chi BC, Casida JE. Melatonin reduces phosphine-induced lipid peroxidation and DNA oxidation in vitro and in vivo in rat brain. J Pineal Res 2002;32: 5362.
  • 31
    Brömme HJ, Mörke W, Peschke E. Transformation of barbituric acid into allaxon by hydroxyl radicals: interaction with melatonin and other hydroxyl radical scavengers. J Pineal Res 2002; 33: 239247.
  • 32
    Bandyopadhyay D, Bandyopadhyay A, Das PK, Reiter RJ. Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J Pineal Res 2002;33: 17.
  • 33
    Tan DX, Manchester LC, Reiter RJ et al. A novel melatonin metabolite cyclic 3-hydroxymelatonin: A biomarker of in vivo hydroxyl radical generation. Biochem Biophys Res Commun 1998; 253: 614620.
  • 34
    Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Librea MA. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003; 34: 110.
  • 35
    Tan DX, Manchester LC, Reiter RJ et al. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Rad Biol Med 2000; 29: 11771185.
  • 36
    Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem Biophys 2001; 34: 237256.
  • 37
    Poeggeler B, Thuerman S, Dose A, Schoenke M, Burkhardt S, Hardeland R. Melatonin's unique radical scavenging properties-roles of its functional substituents as revealed by comparison with its structural analogs. J Pineal Res 2002; 33: 2030.
  • 38
    Limson J, Nyokong T, Daya S. The interaction of melatonin and its precursors with aluminum, cadmium, cooper, iron, lead and zinc: an adsorptive voltametric study. J Pineal Res 1998; 24: 1521.
  • 39
    Parmar P, Limson J, Nyokang T, Daya S. Melatonin protects against copper-mediated free radical damage. J Pineal Res 2002; 32: 237242.
  • 40
    Goda K, Hamane Y, Kishimoto R, Ogishi Y. Radical scavenging properties of tryptophan metabolites: estimation of their radical reactivity. Adv Exp Med Biol 1999; 457: 397402.
  • 41
    Zsizsik BK, Hardeland R. Melatonin and xanthurenic acid protect 2-deoxyribose against destruction by hydroxyl radicals. Action and Redox Properties of Melatonin and Other Aromatic Amino Acid Metabolites. HardelandR ed. Cuvillier, Göttingen, 2001; pp. 142147.
  • 42
    Zsizsik BK, Hardeland R. Comparative studies on kynurenic, xanthurenic and quinaldic acids as scavengers of hyroxyl and ABTS cation radicals. Studies on Antioxidants and Their Metabolites. HardelandR ed, Cuvillier, Göttingen, 1999; pp. 8291.
  • 43
    Fremont L. Biological effects of resveratrol. Life Sci 2000; 66: 663673.
  • 44
    Sgambato A, Ardito R, Faraglea B, Boninsegna A, Wolf FI, Cittadini A. Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage. Mutat Res 2001; 496: 171180.
  • 45
    Burkitt MJ, Duncan J. Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. Arch Biochem Biophys 2000; 381: 253263.
  • 46
    Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationship of flavonoids and phenolic acids. Free Rad Biol Med 1996; 20: 933956.
  • 47
    Liu ZQ, Ma LP, Zhou B, Yang L, Liu ZL. Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein. Chem Phys Lipids 2000; 106: 5363.
  • 48
    Anderson RF, Fisher LJ, Hara Y et al. Green tea catechins partially protect DNA from ·OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. Carcinogenesis 2001; 22: 11891193.
  • 49
    Yoshioca H, Senba Y, Saito K, Kimura T, Hayakawa F. Spin-trapping study on the hydroxyl radical formed from a tea catechin-Cu(II) system. Biosci Biotechnol Biochem 2001; 65: 16971706.
  • 50
    Poeggeler B, Reiter RJ, Hardeland R et al. Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate, trolox, and glutathione. Neuroendocrinol Lett 1995; 17: 8792.
  • 51
    Packer L, Witt E, Tritschler HJ. Alfa-lipoic acid as a biological antioxidant. Free Rad Biol Med 1995; 19: 227250.
  • 52
    Lodge JK, Traber MG, Packer L. Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation. Free Rad Biol Med 1998; 25: 287297.