Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain: a comparative, in vivo study versus vitamin C and E
Article first published online: 23 JUL 2003
Journal of Pineal Research
Volume 35, Issue 2, pages 80–84, September 2003
How to Cite
Rosales-Corral, S., Tan, D.-X., Reiter, R. J., Valdivia-Velázquez, M., Martínez-Barboza, G., Pablo Acosta-Martínez, J. and Ortiz, G. G. (2003), Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain: a comparative, in vivo study versus vitamin C and E. Journal of Pineal Research, 35: 80–84. doi: 10.1034/j.1600-079X.2003.00057.x
- Issue published online: 23 JUL 2003
- Article first published online: 23 JUL 2003
- Received February 6, 2003; accepted March 13, 2003.
- neuroinflammatory cytokines;
- oxidative stress
Abstract: To determine the efficacy of antioxidants in reducing amyloid-β-induced oxidative stress, and the neuroinflammatory response in the central nervous system (CNS) in vivo, three injections of fibrillar amyloid-β (fAβ) or artificial cerebrospinal fluid (aCSF) into the CA1 region of the hippocampus of the rat were made. Concomitantly, one of the three free radical scavengers, i.e. melatonin, vitamin C, or vitamin E was also administered. Besides being a free radical scavenger, melatonin also has immunomodulatory functions. Antioxidant treatment reduced significantly oxidative stress and pro-inflammatory cytokines. There were no marked differences between melatonin, vitamin C, and vitamin E regarding their capacity to reduce nitrites and lipoperoxides. However, melatonin exhibited a superior capacity to reduce the pro-inflammatory response induced by fAβ.