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Keywords:

  • Ca2+ entry;
  • Ca2+ waves;
  • capacitative;
  • caveolae;
  • caveolin;
  • eNOS;
  • signal transduction;
  • store-operated Ca2+ entry

The correct spatial and temporal control of Ca2+ signaling is essential for such cellular activities as fertilization, secretion, motility, and cell division. There has been a long-standing interest in the role of caveolae in regulating intracellular Ca2+ concentration. In this review we provide an updated view of how caveolae may regulate both Ca2+ entry into cells and Ca2+-dependent signal transduction