Anti-Phosphatidylserine/Prothrombin Antibodies are not Frequently Found in Patients with Unexplained Recurrent Miscarriages

Authors

  • AKITO TSUTSUMI,

  • TATSUYA ATSUMI,

  • KENJI ICHIKAWA,

  • HIDETO YAMADA,

  • EMI HIRAYAMA KATO,

  • SEIICHIRO FUJIMOTO,

  • TAKAO KOIKE


Address reprints request to Dr. Akito Tsutsumi, Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

E-mail: atsutsum@md.tsukuba.ac.jp

Abstract

OBJECTIVE: To determine whether the presence of anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) can be a major factor in otherwise unexplained recurrent miscarriages.
PATIENTS AND METHODS: Eighty-one consecutive patients with history of 2 or more recurrent miscarriages were studied. Patients with history of overt thrombotic events were not included. Patients were examined for plausible causes of miscarriages, and titer of IgG, IgM and IgA anti-PS/PT were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS: Thirty-five patients had one or more plausible causes of recurrent miscarriages, including 12 positive for well-established anti-phospholipid antibodies, such as anti-β2-glycoprotein I. None of the patients included in this study was found to be positive for anti-PS/PT.
CONCLUSION: Detection of anti-PS/PT in addition to other anti-phospholipid antibodies does not seem to aid in the evaluation of patients with unexplained recurrent miscarriages.

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