Preeclampsia: A Multifactorial Disease Resulting from the Interaction of the Feto-maternal HLA Genotype and HCMV Infection
Article first published online: 9 OCT 2008
American Journal of Reproductive Immunology
Volume 48, Issue 3, pages 176–183, September 2002
How to Cite
CARREIRAS, M. , MONTAGNANI, S. and LAYRISSE, Z. (2002), Preeclampsia: A Multifactorial Disease Resulting from the Interaction of the Feto-maternal HLA Genotype and HCMV Infection. American Journal of Reproductive Immunology, 48: 176–183. doi: 10.1034/j.1600-0897.2002.01076.x
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
PROBLEM: To clarify the possible influence of human leukocyte antigen (HLA) mother–child genotypes and human cytomegalo virus (HCMV) presence on the development of preeclampsia.
METHODS OF STUDY: One hundred and four DNA samples from mothers with preeclampsia, mothers with a normal history of pregnancies and their neonates were tested by polymerase chain reaction–sequence specific oligonucleotide probes (PCR–SSOP) for HLA-A, -G, -DRB1, -DQA1, -DQB1 alleles. The HCMV sequences were analyzed using a PCR–SSOP method and the four primers described by Chou (Chou S: J Clin Microb 1992; 30:2307–2310).
RESULTS: Compared with their respective controls, a significant increase of DRB1*07 among neonates (Pc=0.05) and of DRB1*07 and/or DRB1*06 among pre-eclamptic mothers (Pc=0.003, RR=8,5) was found. When HCMV sequences were detected in pre-eclamptic mothers carrying those phenotypes the RR increased up to 40. Furthermore, the fetal inheritance of a maternal HLA-G*0104 increased the risk for the appearance of the disease (RR=30; P=0.025).
CONCLUSION: The results suggest that the presence of alleles HLA-G*0104, DRB1*07/06, HCMV sequences and the fetal inheritance of maternal G*0104, should be considered as conditioning factors for the development of preeclampsia.