High Serum Interleukin-8 Levels in Afro-Caribbean Women with Pre-eclampsia. Relations with Tumor Necrosis Factor-α, Duffy Negative Phenotype and Von Willebrand Factor
Article first published online: 15 JAN 2003
American Journal of Reproductive Immunology
Volume 48, Issue 5, pages 319–322, November 2002
How to Cite
Velzing-Aarts, F. V. , Muskiet, F. A.J. , Van Der Dijs, F. P.L. and Duits, A. J. (2002), High Serum Interleukin-8 Levels in Afro-Caribbean Women with Pre-eclampsia. Relations with Tumor Necrosis Factor-α, Duffy Negative Phenotype and Von Willebrand Factor. American Journal of Reproductive Immunology, 48: 319–322. doi: 10.1034/j.1600-0897.2002.01087.x
- Issue published online: 15 JAN 2003
- Article first published online: 15 JAN 2003
- Duffy blood group antigen;
- receptor of chemokines;
- neutrophil activation
Velzing-Aarts FV, van der Dijs FPL, Muskiet FAJ, Duits AJ. High serum interleukin-8 levels in Afro-Caribbean women with pre-eclampsia. Relations with tumor necrosis factor-α, Duffy negative phenotype and von Willebrand factor. AJRI 2002; 48:319–322 © Blackwell Munksgaard, 2002
PROBLEM: Pre-eclampsia is characterized by neutrophil activation. Interleukin-8 (IL-8) is a strong neutrophil chemo-attractant and activator.
METHOD OF STUDY: We measured serum IL-8 in 13 pre-eclamptic Afro-Caribbean women and 13 gestational age-, race- and parity-matched normotensive and non-proteinuric controls. We also determined serum tumor necrosis factor-α (TNF-α), the phenotypes of the IL-8 binding Duffy blood group antigen receptor and the von Willebrand factor (vWF) plasma levels.
RESULTS: Serum IL-8, TNF-α, Duffy negative phenotype frequency and plasma vWF were higher in pre-eclamptic women compared with controls. IL-8 correlated positively with both TNF-α and vWF in the entire study group.
CONCLUSIONS: Higher IL-8 levels in pre-eclampsia may result from increased production (secondary to increased TNF-α levels) and/or reduced clearance (related to a high frequency of Duffy negative phenotype).