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Keywords:

  • Duffy blood group antigen;
  • receptor of chemokines;
  • neutrophil activation

Velzing-Aarts FV, van der Dijs FPL, Muskiet FAJ, Duits AJ. High serum interleukin-8 levels in Afro-Caribbean women with pre-eclampsia. Relations with tumor necrosis factor-α, Duffy negative phenotype and von Willebrand factor. AJRI 2002; 48:319–322 © Blackwell Munksgaard, 2002

PROBLEM: Pre-eclampsia is characterized by neutrophil activation. Interleukin-8 (IL-8) is a strong neutrophil chemo-attractant and activator.

METHOD OF STUDY: We measured serum IL-8 in 13 pre-eclamptic Afro-Caribbean women and 13 gestational age-, race- and parity-matched normotensive and non-proteinuric controls. We also determined serum tumor necrosis factor-α (TNF-α), the phenotypes of the IL-8 binding Duffy blood group antigen receptor and the von Willebrand factor (vWF) plasma levels.

RESULTS: Serum IL-8, TNF-α, Duffy negative phenotype frequency and plasma vWF were higher in pre-eclamptic women compared with controls. IL-8 correlated positively with both TNF-α and vWF in the entire study group.

CONCLUSIONS: Higher IL-8 levels in pre-eclampsia may result from increased production (secondary to increased TNF-α levels) and/or reduced clearance (related to a high frequency of Duffy negative phenotype).