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Correlation of Local Interleukin-1beta Levels with Specific IgA Response Against Gardnerella vaginalis Cytolysin in Women with Bacterial Vaginosis

Authors

  • SABINA CAUCI,

    1. SABINA CAUCI
      SILVIA DRIUSSI
      FRANCO QUADRIFOGLIO
      Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy,
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  • SILVIA DRIUSSI,

    1. SABINA CAUCI
      SILVIA DRIUSSI
      FRANCO QUADRIFOGLIO
      Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy,
    2. SILVIA DRIUSSI
      Azienda Servizi Sanitari N. 4 Medio Friuli, Udine, Italy,
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  • SECONDO GUASCHINO,

    1. SECONDO GUASCHINO
      Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Trieste, Italy,
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  • MIRIAM ISOLA,

    1. MIRIAM ISOLA
      Department of Medical and Morphological Research, School of Medicine, University of Udine, Udine, Italy
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  • FRANCO QUADRIFOGLIO

    1. SABINA CAUCI
      SILVIA DRIUSSI
      FRANCO QUADRIFOGLIO
      Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy,
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Address reprint requests to Sabina Cauci, Dipartimento di Scienze e Tecnologie Biomediche, Facoltà di Medicina e Chirurgia, Piazzale Kolbe 4, 33100 Udine, Italy. E-mail: scauci@mail.dstb.uniud.it

Abstract

PROBLEM: Mucosal immune system activation may represent a critical determinant of adverse sequelae correlated with bacterial vaginosis, as HIV sexual transmission, upper genital tract infections, cervicitis, endometritis, postsurgical infections, and adverse pregnancy outcomes as preterm delivery (PTD), low birth weight (LBW).

METHOD OF STUDY: Levels of interleukin-1beta (IL-1beta), anti-Gardnerella vaginalis hemolysin (Gvh) IgA, pH, Nugent score, and number of leukocytes were measured in vaginal fluids of 60 fertile women with bacterial vaginosis and of 64 healthy controls.

RESULTS: Vaginal IL-1beta levels were nearly 13-fold higher in women with bacterial vaginosis (BV) and were associated with anti-Gvh IgA response. IL-1beta was positively correlated with leukocyte counts in the smear both in healthy and bacterial vaginosis positive women.

CONCLUSIONS: Induction of the proinflammatory cytokine IL-1beta may be a necessary event to elicit an innate immune response to control anaerobic genital tract infections. High levels of vaginal IL-1beta are associated with mounting of an antigen-specific mucosal immune response in women with bacterial vaginosis. Parallel induction of innate and adaptive immune response may be associated with protection from ascent of micro-organisms to the upper genital tract, and from acquiring viral infection through the vaginal tract.

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