T-cell Cytokines in Pregnancy
Article first published online: 25 APR 2002
American Journal of Reproductive Immunology
Volume 47, Issue 5, pages 289–294, May 2002
How to Cite
PICCINNI, M.-P. (2002), T-cell Cytokines in Pregnancy. American Journal of Reproductive Immunology, 47: 289–294. doi: 10.1034/j.1600-0897.2002.01104.x
- Issue published online: 25 APR 2002
- Article first published online: 25 APR 2002
PROBLEM: Immunological mechanisms induced by T cells may play an important role in preimplantation embryo development, in implantation process and in the phenomenon of fetal allograft tolerance.
METHODS: We review existing data on the role of T cells in pregnancy.
RESULTS: The production of LIF, interleukin (IL)-4, IL-10 and M-CSF by the decidual T cells may contribute to the maintenance of pregnancy. T cells are not only confined to the uterus. T cells are also present in cumulus oophorus and are able to produce LIF and IL-4.
CONCLUSIONS: These findings may provide an initial cue in favor of the possibility that different cytokines produced by T cells acting in concert are required to create a suitable microenvironment for the preimplantation embryo development and for the maintenance of pregnancy. T cells could work in parallel with other cells present in the decidua and cumulus suggesting a complex network of hormones, cytokines and cells.