Pro-inflammatory Maternal Cytokine Profile in Preterm Delivery
Article first published online: 9 APR 2003
American Journal of Reproductive Immunology
Volume 49, Issue 5, pages 308–318, May 2003
How to Cite
Makhseed, M., Raghupathy, R., El-Shazly, S., Azizieh, F., Al-Harmi, J. A. and Al-Azemi, M. M. K. (2003), Pro-inflammatory Maternal Cytokine Profile in Preterm Delivery. American Journal of Reproductive Immunology, 49: 308–318. doi: 10.1034/j.1600-0897.2003.00038.x
- Issue published online: 9 APR 2003
- Article first published online: 9 APR 2003
- Submitted June 20, 2002;revised September 11, 2002;accepted September 17, 2002.
- preterm delivery;
- preterm labor;
- T helper 1;
- T helper 2
PROBLEM: The objective of this study was to determine the levels of cytokines produced by maternal peripheral blood mononuclear cells (PBMC) upon stimulation with a mitogen, with autologous placental cells and with a trophoblast antigen extract.
METHOD OF STUDY: Peripheral blood mononuclear cells from 54 women with a history of successful pregnancy and 30 women undergoing preterm delivery (PTD) were stimulated with the mitogen and antigens, and the cytokine levels in mitogen-stimulated culture supernatants assessed.
RESULTS: Significantly higher levels of the type 1 cytokines, interferon (IFN)-γ and interleukin (IL)-2, were produced by the PTD group than by the normal pregnancy group, which on the contrary showed significantly greater production of the type 2 cytokines, IL-4, IL-5 and IL-10. A comparison of the ratios of type 2 to type 1 cytokines is indicative of a type 1 cytokine bias in PTD.
CONCLUSIONS: These data are suggestive of a maternal type 1 cytokine bias in PTD.