Human Seminal Plasma Antibody-Binding Proteins


Address reprint requests to Larry Chamley, Department of obstetrics and Gynaecology. University of Auckland, Auckland, New Zealand. E-mail:;


Problem: The physiological role of antibody-binding proteins in human seminal plasma and the potential role of these proteins in infertility is relatively unknown.

Method of study: Literature on antibody-binding proteins.

Results: Human seminal plasma has a diverse effect on immune function of the reproductive tracts. This review describes (1) the presence of receptors like proteins that can react with monoclonal antibodies against Fcγ receptors III (Fcγ RIII) but are distinctly different from Fcγ RIII; (2) IgG binding factors (IgGBF), a group of low molecular weight proteins that are capable of binding human IgG; (3) other proteins that can bind antibodies, such as prolactin-inducible protein and three other novel proteins that we have discovered. These proteins potentially all have the ability to reduce the interactions between antisperm antibodies and effector components of the immune system, such as phagocytic cells.

Conclusions: Human seminal plasma contains proteins that can bind antibodies. However, to date our knowledge of these proteins especially, whether they have a physiological role in either the male and female reproductive tracts is limited.