Both authors contributed equally to the development of this publication and should be regarded as first author
Evidence for a Correlation between Trophoblast Invasiveness and STAT3 Activity
Article first published online: 9 SEP 2003
American Journal of Reproductive Immunology
Volume 50, Issue 4, pages 316–321, October 2003
How to Cite
Corvinus, F. M., Fitzgerald, J. S., Friedrich, K. and Markert, U. R. (2003), Evidence for a Correlation between Trophoblast Invasiveness and STAT3 Activity. American Journal of Reproductive Immunology, 50: 316–321. doi: 10.1034/j.1600-0897.2003.00099.x
- Issue published online: 9 SEP 2003
- Article first published online: 9 SEP 2003
- Submitted January 21, 2003; revised March 28, 2003; accepted March 28, 2003.
- signal transduction
Problem: Extravillous trophoblast cells are capable of invading decidual tissue during early pregnancy. This property is reminiscent of cancer cells. The invasiveness of trophoblasts, however, extends only to a well-regulated limit. Signal transduction processes underlying this phenomenon are as yet poorly characterized. Many factors involved in trophoblast invasiveness are known to trigger intracellular signaling cascades in other cell types that ultimately lead to the activation of signal transducers and activators of transcription (STATs). STAT3 activity was recently found related to the malignant phenotype of different tumor cells and potentially contributes to their invasive properties.
Method of Study: We investigated the status of STAT3 activity in ex vivo trophoblast cells from first trimester and term placentae employing an electrophoretic mobility shift assay (EMSA) and compared it with that of a highly malignant choriocarcinoma cell line.
Results: Specific DNA binding activity of two STAT3 variants (STAT3α and β) was observed in immature trophoblasts and appeared to be lost in term placentae. The malignant phenotype of choriocarcinoma cells coincides with a high degree of STAT3 activity.
Conclusion: These results suggest a connection between STAT3 activity and trophoblast invasiveness.