This material was presented at the American Society of Transplant Surgeons' Annual Meeting, May 19–21, 1999.
Transplantation of ABO Group A2 Kidneys from Living Donors into Group O and B Recipients$
Article first published online: 5 APR 2002
American Journal of Transplantation
Volume 1, Issue 3, pages 296–299, September 2001
How to Cite
Sorensen, J. B., Grant, W. J., Belnap, L. P., Stinson, J. and Fuller, T. C. (2001), Transplantation of ABO Group A2 Kidneys from Living Donors into Group O and B Recipients. American Journal of Transplantation, 1: 296–299. doi: 10.1034/j.1600-6143.2001.001003296.x
- Issue published online: 5 APR 2002
- Article first published online: 5 APR 2002
- Received 17 December 2000, revised and accepted for publication 21 May 2001
- A2 kidney allocation;
- ABO barrier;
- anti-A titer;
- A antigen expression
Fifteen blood group O and B recipients have been transplanted with kidneys from subtype A2 living donors since April 1992. ABO red cell grouping was performed by local licensed blood banks with A2 subtype determined using an anti-A1 lectin and, retrospectively, by a polymerase chain reaction (PCR)-based molecular method. All grafts functioned immediately and no patient has required dialysis. Three patients each experienced one reversible rejection episode. With the exception of one cardiac death at 9 months and one patient with profound toxicity to calcineurin inhibitors, all allografts continue to function normally. One donor, mistyped as a group A2 using lectin, was by PCR typing an A1O1 nonsecretor; the graft continues to function normally at 30 months. Transplantation of living donor A2 renal allografts into non-A recipients produces excellent long-term allograft survival and expands the potential living donor pool for nonblood group A recipients.