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References

  • 1
    Nikolic B & Sykes M. Bone marrow chimerism and transplantation tolerance. Curr Opin Immunol 1997; 9: 634640.
  • 2
    Wekerle T, Sayegh MH, Hill J et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 1998; 187: 20372044.
  • 3
    Wekerle T, Kurtz J, Ito H et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000; 6: 464469.DOI: 10.1038/74731
  • 4
    Durham M, Bingaman A, Adams A et al. Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000; 165: 14.
  • 5
    Linsley PS & Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Ann Rev Immunol 1993; 11: 191212.
  • 6
    Foy TM, Aruffo A, Bajorath J, Buhlmann JE, Noelle RJ. Immune regulation by CD40 and its ligand gp39. Ann Rev Immunol 1996; 14: 591617.
  • 7
    Larsen CP & Pearson TC. The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr Opin Immunol 1997; 9: 641647.
  • 8
    Markees TG, Phillips NE, Noelle RJ et al. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation 1997; 64: 329335.
  • 9
    Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434438.
  • 10
    Kirk A, Burkly L, Batty D et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686693.DOI: 10.1038/9536
  • 11
    Kenyon N, Chatzipetrou M, Masetti M et al. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci USA 1999; 96: 81328137.
  • 12
    Markees TG, Phillips NE, Gordon EJ et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4+ T cells, interferon-γ, and CTLA4. J Clin Invest 1998; 101: 24462455.
  • 13
    Jones ND, Maurik AV, Hara M et al. CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection. J Immunol 2000; 165: 11111118.
  • 14
    Honey K, Cobbold SP, Waldmann H. CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression. J Immunol 1999; 163: 48054810.
  • 15
    Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rossini AA, Greiner DL. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol 2000; 164: 512521.
  • 16
    Ito H, Kurtz J, Shaffer J, Sykes M. CD4 cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40–CD40L interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J Immunol 2001; 166: 29702981.
  • 17
    Wekerle T, Kurtz J, Sayegh MH et al. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 2001; 166: 23112316.
  • 18
    Blair PJ, Riley JL, Harlan DM et al. CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000; 191: 651660.
  • 19
    Sykes M, Romick ML, Hoyles KA, Sachs DH. In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment. J Exp Med 1990; 171: 645658.
  • 20
    Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH. Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med 1985; 162: 231244.
  • 21
    Tomita Y, Sachs DH, Khan A, Sykes M. Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation. Transplantation 1996; 61: 469477.
  • 22
    Unkeless JC. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 1979; 150: 580596.
  • 23
    Sykes M, Szot GL, Swenson K, Pearson DA. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 1997; 3: 783787.
  • 24
    Acha-Orbea H & Palmer E. Mls: a retrovirus exploits the immune system. Immunol Today 1991; 12: 356361.
  • 25
    Dyson PJ, Knight AM, Fairchild S, Simpson E, Tomonari K. Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes. Nature 1991; 349: 531532.
  • 26
    Bill J, Kanagawa O, Woodland D, Palmer E. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11 bearing T cells. J Exp Med 1989; 169: 14051419.
  • 27
    Tomonari K & Fairchild S. The genetic basis of negative selection of Tcrβ-V11+ T cells. Immunogenetics 1991; 33: 157162.
  • 28
    Xu J, Foy TM, Laman JD et al. Mice deficient for the CD40 ligand. Immunity 1994; 1: 423431.
  • 29
    Van Essen D, Kikutani H, Gray D. CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature 1995; 378: 620623.
  • 30
    Foy TM, Page DM, Waldschmidt TJ et al. An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med 1995; 182: 13771388.
  • 31
    Blazar BR, Taylor PA, Noelle RJ, Vallera DA. CD4 (+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L: CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses. J Clin Invest 1998; 102: 473482.
  • 32
    Wang B, Maile R, Greenwood R, Collins EJ, Frelinger JA. Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells. J Immunol 2000; 164: 12161222.
  • 33
    Trambley J, Bingaman A, Lin A et al. Asialo GM1 (+) CD8 (+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest 1999; 104: 17151722.
  • 34
    Pearson TC, Alexander DZ, Winn KJ, Linsley PS, Lowry RP, Larsen CP. Transplantation tolerance induced by CTLA4Ig. Transplantation 1994; 57: 17011706.
  • 35
    Kirk AD, Harlan DM, Armstrong NN et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94: 87898794.
  • 36
    Elwood ET, Larsen CP, Cho HR et al. Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade. Transplantation 1998; 65: 14221428.
  • 37
    Tomita Y, Khan A, Sykes M. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J Immunol 1994; 153: 10871098.
  • 38
    Khan A, Tomita Y, Sykes M. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Transplantation 1996; 62: 380387.
  • 39
    Manilay JO, Pearson DA, Sergio JJ, Swenson KG, Sykes M. Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a non-myeloablative conditioning regimen. Transplantation 1998; 66: 96102.