• 1
    Pruitt SK, Kirk AD, Bollinger RR et al. The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. Transplantation 1994; 57: 363370.
  • 2
    Leventhal JR, Dalmasso AP, Cranwell JW et al. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation 1993; 55: 857866.
  • 3
    Cozzi E, Tucker AW, Langford GA et al. Characterization of pigs transgenic for human decay-accelerating factor. Transplantation 1997; 64: 13831392.
  • 4
    Schmoekel M, Bhatti FN, Zaidi A et al. Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation 1998; 65: 15701577.
  • 5
    Waterworth PD, Dunning J, Tolan M et al. Life-supporting pig-to-baboon heart xenotransplantation. J Heart Lung Transplant 1998; 17: 12011207.
  • 6
    Loss M, Vangerow B, Schmidtko J et al. Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model. Xenotransplantation 2000; 7: 186196.
  • 7
    Soin B, Vial CM, Masroor S et al. Peri-operative TP10 (sCR1) improves early graft function and in combination with RAD and neoral extends survival after prolonged cold ischaemia in hDAF-transgenic pig to primate renal xenotransplantation. Transplantation 2000; 69: S252.
  • 8
    Vangerow B, Hecker JM, Lorenz R et al. C1-inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of hDAF-transgenic porcine kidneys. Xenotransplantation 2001; 8: 266272.
  • 9
    Vanhove B, De Martin R, Lipp J, Bach FH. Human xenoreactive natural antibodies of the IgM isotype activate pig endothelial cells. Xenotransplantation 1994; 1: 1723.
  • 10
    Palmetshofer A, Galili U, Dalmasso AP, Robson SC, Bach FH. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type I activation. Transplantation 1998; 65: 844853.
  • 11
    Palmetshofer A, Galili U, Dalmasso AP, Robson SC, Bach FH. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type II activation. Transplantation 1998; 65: 971978.
  • 12
    Shimizu A, Meehan SM, Kozlowski T et al. Acute humoral xenograft rejection: destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts. Lab Invest 2000; 80: 815830.
  • 13
    Lin SS, Weidner BC, Byrne GW et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 1998; 101: 17451756.
  • 14
    Lin SS, Hanaway MJ, Gonzalez SG et al. The role of anti-Galalpha1–3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation 2000; 70: 16671674.
  • 15
    Collins BH, Parker W, Platt JL. Characterization of porcine endothelial cell determinants recognized by human natural antibodies. Xenotransplantation 1994; 1: 3646.
  • 16
    Cooke SP, Hederer RA, Pearson JD, Savage COS. Characterization of human IgG-binding xenoantigens expressed by porcine aortic endothelial cells. Transplantation 1995; 60: 12741284.
  • 17
    Polejaeva IA, Chen SH, Vaught TD et al. Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 2000; 407: 8690.DOI: 10.1038/35024082
  • 18
    Platt JL, Vercellotti GM, Dalmasso AP et al. Transplantation of discordant xenografts; a review of progress. Immunol Today 1990; 11: 450456.
  • 19
    Soares MP, Lin Y, Sato K, Stuhlmeier KM, Bach FH. Accommodation. Immunol Today 1999; 20: 434437.
  • 20
    Buelow R, Tullius SG, Volk H-D. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am J Transplant 2001; 1: 313315.
  • 21
    Dorling A, Lechler RI. Disordered thromboregulation after xenografting. Curr Opin Organ Transplant 2001; 6: 36.
  • 22
    Rose AG, Cooper DK. Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection. Xenotransplantation 2000; 7: 3141.
  • 23
    Cowan PJ, Chen CG, Shinkel TA et al. Knock out of alpha1,3-galactosyltransferase or expression of alpha1,2-fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection. Transplantation 1998; 65: 15991604.
  • 24
    Cowan PJ, Aminia A, Barlow H et al. Renal xenografts from triple transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 2000; 69: 25042515.
  • 25
    Siegel JB, Grey ST, Lesnikoski BA et al. Xenogeneic endothelial cells activate human prothrombin. Transplantation 1997; 64: 888896.
  • 26
    Robson SC, Cooper DK, D'Apice AJ. Disordered regulation of coagulation and platelet activation in xenotransplantation. Xenotransplantation 2000; 7: 166176.
  • 27
    Bennet W, Sundberg B, Lundgren T et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000; 69: 711719.
  • 28
    Bennet W, Bjorkland A, Sundberg B et al. A comparison of fetal and adult porcine islets with regard to Gal alpha (1–3) Gal expression and the role of human immunoglobulins and complement in islet cell cytotoxicity. Transplantation 2000; 69: 17111717.
  • 29
    Contreras JL, Eckhoff DE, Cartner S et al. Long-term functional islet mass and metabolic function after xenoislet transplantation in primates. Transplantation 2000; 69: 195201.
  • 30
    Dorling A, Lechler RI. T cell-mediated xenograft rejection: specific tolerance is probably required for long term xenograft survival. Xenotransplantation 1998; 5: 234245.
  • 31
    Smith RM, Mandel TE. Pancreatic islet xenotransplantation: the potential for tolerance induction. Immunol Today 2000; 21: 4248.
  • 32
    Dorling A, Lombardi G, Binns R, Lechler RI. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 1996; 26: 13781387.
  • 33
    Vaughan AN, Malde P, Rogers NJ, Jackson IM, Lechler RI, Dorling A. Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. J Immunol 2000; 165: 31753181.
  • 34
    Rogers NJ, Mirenda V, Jackson I, Dorling A, Lechler RI. Costimulatory blockade by the induction of an endogenous xenospecific antibody response. Nat Immunol 2000; 1: 163168.DOI: 10.1038/77853
  • 35
    Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307: 168170.
  • 36
    Spitzer TR, Delmonico F, Tolkoff-Rubin N et al. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999; 68: 480484.
  • 37
    Yang YG, DeGoma E, Ohdan H et al. Tolerization of anti-Galalpha1–3Gal natural antibody-forming B cells by induction of mixed chimerism. J Exp Med 1998; 187: 13351342.
  • 38
    Ohdan H, Yang YG, Swenson KG, Kitamura H, Sykes M. T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Transplantation 2001; 71: 15321542.
  • 39
    Mohiuddin MM, Qin Y, Qian X, Meng Y, DiSesa VJ. Long-term survival of cardiac xenografts in fully xenogeneic (mouse [RIGHTWARDS ARROW]rat) bone marrow chimeras. Ann Thorac Surg 2001; 72: 740745.
  • 40
    Sykes M. Mixed chimerism and transplant tolerance. Immunity 2001; 14: 417424.
  • 41
    Buhler L, Goepfert C, Kitamura H et al. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant, 2001; 27: 12271236.
  • 42
    Alwayn IP, Buhler L, Appel J3 et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation 2001; 71: 16011609.
  • 43
    Emery DW, Holley K, Sachs DH. Enhancement of swine progenitor chimerism in mixed swine/human bone marrow cultures with swine cytokines. Exp Hematol 1999; 27: 13301337.
  • 44
    Chen AM, Zhou Y, Swenson K, Sachs DH, Sykes M, Yang YG. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation 2000; 69: 24842490.
  • 45
    Bannerjee PT, Ierino FL, Kaynor GC et al. Expression of swine MHC class II genes in a cynomolgus monkey: Retrovirus-mediated gene therapy in a preclinical transplantation model. Xenotransplantation 1997; 4: 174.
  • 46
    Ierino FL, Gojo S, Banerjee PT et al. Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers. Transplantation 1999; 67: 11191128.
  • 47
    Khan A, Sergio JJ, Zhao Y et al. Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance. Transplantation 1997; 63: 124131.
  • 48
    Zhao Y, Rodriguez BJ, Swenson K et al. The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice. Transplantation 2000; 69: 14471451.
  • 49
    Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997; 3: 282286.
  • 50
    Patience C, Patton GS, Takeuchi Y et al.. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancet 1998; 352: 699701.
  • 51
    Heneine W, Tibell A, Switzer WM et al. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 1998; 352: 695699.
  • 52
    Paradis K, Langford G, Long Z et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 1999; 285: 12361241.DOI: 10.1126/science.285.5431.1236
  • 53
    Elliot RB, Escobar L, Garkavenko O et al. No evidence of infection with porcine endogenous retrovirus in recipients of encapsulated porcine islet xenografts. Cell Transplant 2000; 9: 895901.
  • 54
    Van Der Laan LJ, Lockey C, Griffeth BC et al. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature 2000; 407: 9094.
  • 55
    Patience C, Greenstein J. PERV clarification. Nat Biotechnol 2001; 19: 508.
  • 56
    Weiss RA. Certain promise and uncertain peril. The debate on xenotransplantation. EMBO Rep 2000; 1: 24.