Supported in part by the Centers for Disease Control and Prevention Emerging Infection Food Net Program (IRB protocol no. 97-1-09).
Calicivirus Enteritis in an Intestinal Transplant Recipient
Article first published online: 28 MAY 2003
American Journal of Transplantation
Volume 3, Issue 6, pages 764–768, June 2003
How to Cite
Kaufman, S. S., Chatterjee, N. K., Fuschino, M. E., Magid, M. S., Gordon, R. E., Morse, D. L., Herold, B. C., LeLeiko, N. S., Tschernia, A., Florman, S. S., Gondolesi, G. E. and Fishbein, T. M. (2003), Calicivirus Enteritis in an Intestinal Transplant Recipient. American Journal of Transplantation, 3: 764–768. doi: 10.1034/j.1600-6143.2003.00112.x
- Issue published online: 28 MAY 2003
- Article first published online: 28 MAY 2003
- Received 7 November 2002, revised 15 December 2002 and accepted for publication 6 January 2003
- Norwalk virus;
Protracted diarrhea of uncertain etiology is a significant problem following intestinal transplantation. We report an infant who developed severe secretory diarrhea 178 days after intestinal transplantation that persisted for more than 120 days. Repeated allograft biopsies demonstrated only nonspecific inflammation. Enzyme immunoassay (for rotavirus), culture, and reverse transcription polymerase chain reaction [calicivirus (Norwalk-like virus)] were used to identify the allograft viral infection. A heavy density of calicivirus RNA nucleotide sequences (genogroup II, strain Miami Beach) was isolated from the jejunal and ileal allograft. Following a reduction in immunosuppressive therapy, diarrhea and enteritis remitted in association with the disappearance of all calicivirus RNA sequences. Calicivirus may cause severe allograft dysfunction in intestinal transplant recipients.