Screening for Prostate, Breast and Colorectal Cancer in Renal Transplant Recipients
Article first published online: 8 MAY 2003
American Journal of Transplantation
Volume 3, Issue 5, pages 619–625, May 2003
How to Cite
Kiberd, B. A., Keough-Ryan, T. and Clase, C. M. (2003), Screening for Prostate, Breast and Colorectal Cancer in Renal Transplant Recipients. American Journal of Transplantation, 3: 619–625. doi: 10.1034/j.1600-6143.2003.00118.x
- Issue published online: 8 MAY 2003
- Article first published online: 8 MAY 2003
- Received 15 August 2002, revised 4 December 2002 and accepted for publication 4 January 2003
- Cancer screening;
- kidney transplantation;
- life expectancy;
- medical decision analysis
American Society of Transplantation guidelines recommend screening renal transplant recipients for breast, colorectal and prostate cancer. However there is a lack of evidence to support this practice.
Computer simulation modeling was used to estimate the years of life lost as a result of these cancers in 50-year-old renal transplant recipients and subjects in the general population.
Renal transplant recipients lost fewer years of life to cancer than people in the general population largely because of reduced life expectancy. In nondiabetic transplant recipients, loss of life as a result of these cancers was comparable with that in the general population only under assumptions of increased cancer incidence and cancer-specific mortality risks. Even with two-fold higher cancer incidence and disease-specific mortality risks, diabetic transplant recipients lost considerably fewer life years to cancer than those in the general population.
Recommended cancer screening for the general population may not yield the expected benefits in the average renal transplant recipient but the benefits will be considerably higher than for patients on dialysis. Transplanted patients at above-average cancer risk in good health may achieve the benefits of screening that are seen in the general population.