• 1
    Calne RY, White HJ, Yoffa DE. et al. Prolonged survival of liver transplants in the pig. BMJ 1967; 4: 645648.
  • 2
    Qian S, Demetris AJ, Murase N, Rao AS, Fung JJ, Starzl TE. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994; 19: 916924.
  • 3
    Qian SG, Fung JJ, Demetris AV, Ildstad ST, Starzl TE. Orthotopic liver transplantation in the mouse. Transplant 1991; 52: 562564.
  • 4
    Kamada N, Davies HS, Roser B. Reversal of transplantation immunity by liver grafting. Nature 1981; 292: 840842.
  • 5
    Sun J, Sheil AGR, Wang C et al. Tolerance to rat liver allografts. IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes. Transplant 1996; 62: 17251730.
  • 6
    Woo J, Lu L, Rao AS et al. Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells. Transplant 1994; 58: 484491.
  • 7
    Mathukumaran G, Kotenko S, Donnelly R, Ihle JN, Pestka S. Chimeric erythropoietin-interferon γ receptors reveal differences in functional architecture of intracellular domains for signal transduction. J Biol Chem 1997; 272: 49934999.
  • 8
    Benson EM, Colvin RB, Russell PS. Induction of IA antigens in murine renal transplants. J Immunol 1985; 134: 79.
  • 9
    Konieczny BT, Dai Z, Elwood ET et al. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998; 160: 20592064.
  • 10
    Hassan AT, Dai Z, Konieczny BT et al. Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: implications for long-term allograft acceptance. Transplant 1999; 68: 124129.
  • 11
    Halloran PF, Autenried P, Ramassar V, Urmson J, Cockfield S. Local T cell responses induce widespread MHC expression. Evidence that IFN-γ induces its own expression in remote sites. J Immunol 1992; 148: 38373846.
  • 12
    Belitsky P, Miller SM, Gupta R, Lee S, Ghose T. Induction of MHC class II expression in recipient tissues caused by allograft rejection. Transplant 1990; 49: 472476.
  • 13
    Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG. Acute rejection of vascularized heart allografts in the absence of IFNgamma. Transplant 1996; 62: 19081911.
  • 14
    Wang H, DeVries ME, Deng S et al. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med 2000; 6: 549555.
  • 15
    Halloran PF, Afrouzian M, Ramassar V et al. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 2001; 158: 215226.
  • 16
    Afrouzian M, Ramassar V, Urmson J, Zhu LF, Halloran PF. Transcription factor IRF-1 in kidney transplants mediates resistance to graft necrosis during rejection. J Am Soc Nephrol 2002; 13: 11991209.
  • 17
    Ring GH, Saleem S, Dai Z et al. Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplant 1999; 67: 13621365.
  • 18
    Zand MS, Li Y, Hancock W et al. Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts. Transplant 2000; 70: 13781381.
  • 19
    Paineau J, Priestley C, Fabre J et al. Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts. J Heart Lung Transplant 1991; 10: 424430.
  • 20
    Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 1993; 259: 17391742.
  • 21
    Huang S, Hendriks W, Althage A et al. Immune response in mice that lack the interferon-gamma receptor. Science 1993; 259: 17421745.
  • 22
    Omoto K, Nishimura Y, Nomoto K et al. Anti-CD4 monoclonal antibody reduces the dose of cyclophosphamide required to induce tolerance to H-2 haplotype identical skin allografts in mice. Immunobiology 1996; 195: 1632.
  • 23
    Demetrius AJ, Batts KP, Dhillon AP et al. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997; 25: 658663.
  • 24
    Halloran PF, Goes N, Urmson J et al. MHC expression in organ transplants: lessons from the knock-out mice. Transplant Proc 1997; 29: 10411044.
  • 25
    Jephthah-Ochola J, Urmson J, Farkas S, Halloran PF. Regulation of MHC expression in vivo. Bacterial lipopolysaccharide induces class I and II MHC products in mouse tissues by a T cell- independent, cyclosporine-sensitive mechanism. J Immunol 1988; 141: 792800.
  • 26
    Cockfield SM, Ramassar V, Urmson J, Halloran PF. Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma. J Immunol 1989; 142: 11201128.
  • 27
    Salacinski PR, McLean C, Sykes JE, Clement-Jones VV, Lowry PJ. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen). Anal Biochem 1981; 117: 136146.
  • 28
    Halloran PF, Urmson J, Ramassar V, Laskin C, Autenried P. Increased class I and class II MHC products and mRNA in kidneys of MRL- lpr/lpr mice during autoimmune nephritis and inhibition by cyclosporine. J Immunol 1988; 141: 23032312.
  • 29
    Morris RJ, Williams AF. Antigens on mouse and rat lymphocytes recognized by rabbit antiserum against rat brain: the quantitative analysis of a xenogeneic antiserum. EJI 1975; 5: 274281.
  • 30
    Halloran PF, Miller LW, Urmson J et al. IFN-gamma alters the pathology of graft rejection: protection from early necrosis. J Immunol 2001; 166: 70727081.
  • 31
    Skoskiewicz M, Colvin RB, Schneeberger EE, Russell PS. Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by γ interferon. J Exp Med 1985; 162: 16451664.
  • 32
    Icard P, Sawyer GJ, Houssin D, Fabre JW. Marked differences between orthotopic and heterotopic auxiliary liver allografts in the induction of class II MHC antigens on hepatocytes. Transplant Proc 1990; 22: 1935.
  • 33
    Halloran PF, Urmson JR, Afrouzian M, Zhu L-F. Transcription factor IRF-1 plays a critical role in maintaining transplant viability during acute rejection. Transplantation 2000; 69: S127[abstract].
  • 34
    Bishop GA, Waugh JA, Landers DV, Krensky AM, Hall BM. Microvascular destruction in renal transplant rejection. Transplant 1989; 48: 408414.
  • 35
    Matsumoto Y, McCaughan GW, Painter DM, Bishop GA. Evidence that portal tract microvascular destruction precedes bile duct loss in human liver allograft rejection. Transplant 1993; 56: 6975.
  • 36
    Halloran PF, Urmson JR, Zhu L-F. Cell mediated damage to the microcirculation during rejection: protective role of IFN-γ. J Am Soc Nephrol 2002; 13: 355A[abstract] .
  • 37
    Lanier LL. NK cell receptors. Annu Rev Immunol 1998; 16: 359393.
  • 38
    Maier S, Tertilt C, Chambron N et al. Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/- mice. Nat Medical 2001; 7: 557562.
  • 39
    Kamada N. The immunology of experimental liver transplantation in the rat. Immunology 1985; 55: 369389.
  • 40
    Davies HS, Pollard SG, Calne RY. Soluble HLA antigens in the circulation of liver graft recipients. Transplant 1989; 47: 524527.
  • 41
    Pollard SG, Davies HF, Calne RY. Peroperative appearance of serum class I antigen during liver transplantation. Transplant 1990; 49: 659660.
  • 42
    Sumimoto R, Kamada N. Specific suppression of allograft rejection by soluble class I antigen and complexes with monoclonal antibody. Transplant 1990; 50: 678682.
  • 43
    Sumimoto R, Kamada N. Evidence that soluble class I antigen in donor serum induces the suppression of heart allograft rejection in rats. Immunol Lett 1990; 26: 8184.
  • 44
    Armstrong HE, Bolton EM, McMillan I, Spencer SC, Bradley JA. Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration and rapid induction of both class I and class II MHC antigens. J Exp Med 1987; 164: 891907.
  • 45
    Refaeli Y, Van Parijs L, Alexander SI, Abbas AK. Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med 2002; 196: 9991005.
  • 46
    Badovinac VP, Tvinnereim AR, Harty JT. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 2000; 290: 13541358.
  • 47
    Bishop DK, Chan WS, Eichwald EJ, Orosz CG. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40–CD40 ligand interactions. J Immunol 2001; 166: 32483255.
  • 48
    Badovinac VP, Porter BB, Harty JT. Programmed contraction of CD8 (+) T cells after infection. Nat Immunol 2002; 3: 619626.
  • 49
    Blattman JN, Cheng LE, Greenberg PD. CD8 (+) T cell responses: it's all downhill after their prime. Nat Immunol 2002; 3: 601602.
  • 50
    Russell PS, Chase CM, Colvin RB, Plate JMD. Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants. J Exp Med 1978; 147: 14491468.
  • 51
    Grohmann U, Orabona C, Fallarino F et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002; 3: 10971101.
  • 52
    Raisanen-Sokolowski A, Glysing-Jensen T, Koglin J, Russell ME. Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipients. Am J Pathol 1998; 152: 359365.
  • 53
    Nagano H, Libby P, Taylor MK et al. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol 1998; 152: 11871197.