1600-6143/asset/olbannerleft.gif?v=1&s=c46a3f174bfd9c6eb548cc809401524372c32e90)
1600-6143/asset/olbannerright.gif?v=1&s=9fc9790fa8ad5ef85aeaf408bf0d3d969d2fc012)
Viewpoint: Therapeutic Implications of CTLA-4 Compartmentalization
Article first published online: 30 JUN 2003
DOI: 10.1034/j.1600-6143.2003.00182.x
Additional Information
How to Cite
Baroja, M. L. and Madrenas, J. (2003), Viewpoint: Therapeutic Implications of CTLA-4 Compartmentalization. American Journal of Transplantation, 3: 919–926. doi: 10.1034/j.1600-6143.2003.00182.x
Publication History
- Issue published online: 30 JUN 2003
- Article first published online: 30 JUN 2003
- Received 19 November 2002, revised and accepted for publication 7 April 2003
- Abstract
- Article
- References
- Cited By
Keywords:
- CTLA-4;
- immune tolerance;
- T cell activation;
- transplantation
Understanding the regulatory events involved in the activation and inactivation of T cells is crucial to develop therapeutic approaches for autoimmune diseases and for organ transplantation. Co-stimulatory signals delivered through the CD28 receptor and inhibitory signals through CTLA-4 are required for the proper modulation of T cell responses and the induction and maintenance of peripheral tolerance. Manipulation of these signals is emerging as a potential strategy to prevent allograft rejection in different animal models. Recent data on the compartmentalization and the structural features of CTLA-4 within T cells provides critical information not only on the molecular basis of T cell inactivation by CTLA-4, but also on the key requirements for the successful development of therapeutic strategies targeting this molecule.